{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:55:29Z","timestamp":1761292529190},"reference-count":14,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":2138,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p>The serum mineral levels, glucose disappearance rate (<jats:italic>k<\/jats:italic><jats:sub>g<\/jats:sub>), total area under the glucose (\u0394G) and insulin (\u0394I) curves, and static insulin secretion were compared among rats fed a Mg-deficient diet for 6 (DF-6) or 11 (DF-11) weeks, and rats fed a control diet for the same periods (CO-6 and CO-11 groups). No change in glucose homeostasis was observed among DF-6, CO-6 and CO-11 rats. DF-11 rats showed an elevated<jats:italic>k<\/jats:italic><jats:sub>g<\/jats:sub>and a reduced \u0394G and \u0394I. For evaluating the effect of supplementation, rats fed a control or Mg-deficient diet for 6 weeks were then fed a Mg- supplemented diet for 5 weeks (SCO and SDF groups respectively). The serum Mg levels in SDF rats were similar to those in CO-11 and SCO rats, but higher than in the DF-11 group. SDF rats showed similar<jats:italic>k<\/jats:italic><jats:sub>g<\/jats:sub>, \u0394G and \u0394I compared with the CO-11 and SCO groups. However, a significantly lower<jats:italic>k<\/jats:italic><jats:sub>g<\/jats:sub>and higher \u0394G and \u0394I were observed in SDF compared with DF-11 rats. Basal and 8.3 mmol glucose\/l-stimulated insulin secretion by islets from DF-11 rats were higher than by islets from CO-11 rats. These results indicate that moderate Mg depletion for a long period may increase the secretion and sensitivity to insulin, while Mg supplementation in formerly Mg-deficient rats may prevent the increase in sensitivity and secretion of insulin.<\/jats:p>","DOI":"10.1079\/bjn2000294","type":"journal-article","created":{"date-parts":[[2008,5,15]],"date-time":"2008-05-15T16:08:16Z","timestamp":1210867696000},"page":"549-552","source":"Crossref","is-referenced-by-count":4,"title":["Magnesium deficiency improves glucose homeostasis in the rat: studies<i>in vivo<\/i>and in isolated islets<i>in vitro<\/i>"],"prefix":"10.1017","volume":"85","author":[{"given":"Marise A. 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R.","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114501000794_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/102.5.616"},{"key":"S0007114501000794_ref011","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.2.133"},{"key":"S0007114501000794_ref014","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.22.2.158"},{"key":"S0007114501000794_ref012","doi-asserted-by":"publisher","DOI":"10.1007\/BF00257788"},{"key":"S0007114501000794_ref001","doi-asserted-by":"publisher","DOI":"10.1210\/endo-101-1-203"},{"key":"S0007114501000794_ref005","doi-asserted-by":"publisher","DOI":"10.2337\/diab.17.11.673"},{"key":"S0007114501000794_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(87)90011-4"},{"key":"S0007114501000794_ref007","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1017\/S0007114598001342","article-title":"Protein deficiency during pregnancy and lactation impairs glucose-induced insulin secretion but increases the sensitivity to insulin in weaned rats","volume":"80","author":"Latorraca","year":"1998","journal-title":"British Journal of Nutrition"},{"key":"S0007114501000794_ref003","first-page":"83","article-title":"Magnesium supplementation in the treatment of diabetes","author":"Garber","year":"1995","journal-title":"Diabetes Care"},{"key":"S0007114501000794_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(96)90156-0"},{"key":"S0007114501000794_ref004","first-page":"17","article-title":"In vitro relationship between magnesium and insulin secretion","volume":"7","author":"Ishizuka","year":"1994","journal-title":"Magnesium Research"},{"key":"S0007114501000794_ref009","first-page":"E925","article-title":"Magnesium deficiency enhances basal glucose disposal in the rat","volume":"268","author":"Lowney","year":"1995","journal-title":"American Journal of Physiology"},{"key":"S0007114501000794_ref010","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6719.230"},{"key":"S0007114501000794_ref013","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401757"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114501000794","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T12:06:55Z","timestamp":1557576415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114501000794\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["S0007114501000794"],"URL":"https:\/\/doi.org\/10.1079\/bjn2000294","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}