{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:30:08Z","timestamp":1760203808560},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":1650,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p>Free radicals and reactive species produced<jats:italic>in vivo<\/jats:italic>can trigger cell damage and DNA modifications resulting in carcinogenesis. Dietary antioxidants trap these species limiting their damage. The present study evaluated the role of vitamins C and E in the prevention of potentially premalignant modifications to DNA in the human stomach by supplementing patients who, because of hypochlorhydria and possible depletion of gastric antioxidants, could be at increased risk of gastric cancer. Patients undergoing surveillance for Barrett's oesophagus (<jats:italic>n<\/jats:italic>100), on long-term proton pump inhibitors were randomized into two groups: vitamin C (500 mg twice\/d) and vitamin E (100 mg twice\/d) for 12 weeks (the supplemented group) or placebo. Those attending for subsequent endoscopy had gastric juice, plasma and mucosal measurements of vitamin levels and markers of DNA damage. Seventy-two patients completed the study. Plasma ascorbic acid, total vitamin C and vitamin E were elevated in the supplemented group consistent with compliance. Gastric juice ascorbic acid and total vitamin C levels were raised significantly in the supplemented group (<jats:italic>P<\/jats:italic>=0\u00b701) but supplementation had no effect on the mucosal level of this vitamin. However, gastric juice ascorbic acid and total vitamin C were within normal ranges in the unsupplemented group. Mucosal malondialdehyde, chemiluminescence and DNA damage levels in the comet assay were unaffected by vitamin supplementation. In conclusion, supplementation does not affect DNA damage in this group of patients. This is probably because long-term inhibition of the gastric proton pump alone does not affect gastric juice ascorbate and therefore does not increase the theoretical risk of gastric cancer because of antioxidant depletion.<\/jats:p>","DOI":"10.1079\/bjn2002619","type":"journal-article","created":{"date-parts":[[2003,4,9]],"date-time":"2003-04-09T11:46:34Z","timestamp":1049888794000},"page":"265-271","source":"Crossref","is-referenced-by-count":15,"title":["Dietary antioxidants and DNA damage in patients on long-term acid-suppression therapy: a randomized controlled study"],"prefix":"10.1017","volume":"88","author":[{"given":"K. L. M.","family":"White","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Chalmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. G.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Everett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Neville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Naylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"Sutcliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. F.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. C.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Schorah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114502001642_ref034","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.8.1038"},{"key":"S0007114502001642_ref006","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.11.1467"},{"key":"S0007114502001642_ref007","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.5.524"},{"key":"S0007114502001642_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(99)00248-8"},{"key":"S0007114502001642_ref039","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2670(92)85052-8"},{"key":"S0007114502001642_ref020","first-page":"423","article-title":"N-nitroso compound formation in human gastric juice","volume":"8","author":"Kyrtopoulos","year":"1989","journal-title":"Cancer Surveys"},{"key":"S0007114502001642_ref009","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.3.559"},{"key":"S0007114502001642_ref032","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/12.2.193"},{"key":"S0007114502001642_ref003","first-page":"437","article-title":"The precancerous process","volume":"2","author":"Correa","year":"1983","journal-title":"Cancer Survey"},{"key":"S0007114502001642_ref025","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.4.436"},{"key":"S0007114502001642_ref017","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072628"},{"key":"S0007114502001642_ref024","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.9367"},{"key":"S0007114502001642_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.6.1086"},{"key":"S0007114502001642_ref029","first-page":"217","article-title":"Ascorbic acid metabolism in the human stomach","volume":"60","author":"Schorah","year":"1997","journal-title":"Acta Gastro-Enterologica Belgica"},{"key":"S0007114502001642_ref016","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.5.1035"},{"key":"S0007114502001642_ref008","first-page":"19","volume-title":"DNA and Free Radicals","author":"Dizdaroglu","year":"1993"},{"key":"S0007114502001642_ref022","first-page":"443","article-title":"Effect of 6 month supplementation with different combinations of an association of antioxidant nutrients on biochemical parameters and markers of the antioxidant defence system in the elderly. The Geriatrie\/Min. Vit. Axon Network","volume":"50","author":"Monget","year":"1996","journal-title":"European Journal of Clinical Nutrition"},{"key":"S0007114502001642_ref037","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/clinchem\/34.2.377","article-title":"Concurrent liquid chromatographic assay of retinal, \u03b1-tocopherol, \u03b2-carotene, \u03b1-carotene, lycopene and \u03b2-cryptoxanthin in plasma, with tocopherol acetate as internal standard","volume":"34","author":"Thurnham","year":"1988","journal-title":"Clinical Chemistry"},{"key":"S0007114502001642_ref005","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactoral process","volume":"52","author":"Correa","year":"1992","journal-title":"Cancer Research"},{"key":"S0007114502001642_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92211-X"},{"key":"S0007114502001642_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70064-8"},{"key":"S0007114502001642_ref035","doi-asserted-by":"publisher","DOI":"10.3109\/00365528509093749"},{"key":"S0007114502001642_ref040","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(76)90049-1"},{"key":"S0007114502001642_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)80595-7"},{"key":"S0007114502001642_ref010","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.6.768"},{"key":"S0007114502001642_ref038","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.2.171"},{"key":"S0007114502001642_ref014","first-page":"A2","article-title":"The measurement of DNA single strand breaks, using the 'COMET' assay, in Helicobacter pylori associated gastritis","volume":"38","author":"Everett","year":"1996","journal-title":"Gut"},{"key":"S0007114502001642_ref028","first-page":"92","article-title":"Micronutrients, antioxidants and risk of cancer","volume":"52","author":"Schorah","year":"1995","journal-title":"Bibliotheca Nutritio Dieta"},{"key":"S0007114502001642_ref013","first-page":"369","article-title":"Levels of malondialdehyde-deoxyganosine in the gastric mucosa \u2013 relationship with lipid peroxidation, ascorbic acid and Helicobacter pylori Cancer Epidemiology","volume":"10","author":"Everett","year":"2001","journal-title":"Biomarkers and prevention"},{"key":"S0007114502001642_ref030","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/53.1.287S"},{"key":"S0007114502001642_ref021","doi-asserted-by":"publisher","DOI":"10.1177\/000456329002700301"},{"key":"S0007114502001642_ref036","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(00)80016-3"},{"key":"S0007114502001642_ref012","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2001477"},{"key":"S0007114502001642_ref026","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/65.1.101"},{"key":"S0007114502001642_ref027","first-page":"31A","article-title":"Gastric juice ascorbic acid; Effects of disease, hypochlorhydria and stimulation of gastric secretion","volume":"49","author":"Schorah","year":"1990","journal-title":"Proceedings of the Nutrition Society"},{"key":"S0007114502001642_ref033","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90071-1"},{"key":"S0007114502001642_ref004","first-page":"3554","article-title":"A human model of gastric carcinogenesis","volume":"48","author":"Correa","year":"1988","journal-title":"Cancer Research"},{"key":"S0007114502001642_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(00)00041-3"},{"key":"S0007114502001642_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(88)90265-0"},{"key":"S0007114502001642_ref011","first-page":"10","article-title":"Reactive oxygen species (ROS) activity and damage in Helicobacter pylori associated gastritis: effect of eradication therapy","volume":"35","author":"Drake","year":"1995","journal-title":"Gut"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114502001642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T13:36:03Z","timestamp":1584538563000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114502001642\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["S0007114502001642"],"URL":"https:\/\/doi.org\/10.1079\/bjn2002619","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}