{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:39:31Z","timestamp":1791135571524,"version":"4.1.0"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":1589,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>The present study was designed to evaluate the effect of increased viscosity of the intestinal digesta on proliferation of enterotoxigenic<jats:italic>Escherichia coli<\/jats:italic>and the intestinal spirochaete<jats:italic>Brachyspira pilosicoli<\/jats:italic>in weaned pigs. Pigs were fed an experimental diet based on cooked white rice (R), which was supplemented with carboxymethylcellulose (CMC; 40 g\/kg diet) to increase digesta viscosity. Thirty-six piglets weaned at 21 d of age were divided into six groups, three of which were fed R and three R+CMC. Addition of CMC increased digesta viscosity in the ileum (<jats:italic>P<\/jats:italic>=0\u00b701), caecum (<jats:italic>P<\/jats:italic>=0\u00b70007) and colon (<jats:italic>P<\/jats:italic>=0\u00b70035), without increasing indices of large intestinal fermentation. Pigs fed R+CMC developed a natural infection with enterotoxigenic<jats:italic>E. coli<\/jats:italic>after weaning and had more (<jats:italic>P<\/jats:italic>&lt;0\u00b70001) diarrhoea than pigs fed R. Subsequent experimental infection of two groups of pigs with<jats:italic>B. pilosicoli<\/jats:italic>resulted in more (<jats:italic>P<\/jats:italic>&lt;0\u00b70001) colonisation in pigs fed R+CMC than R. At this time, all pigs fed R+CMC had wetter (<jats:italic>P<\/jats:italic>&lt;0\u00b70001) faeces than those fed R, irrespective of whether they were infected with<jats:italic>B. pilosicoli<\/jats:italic>, but infected pigs also had an increased (<jats:italic>P<\/jats:italic>=0\u00b7025) number of days with diarrhoea post-infection irrespective of diet. In pigs fed R+CMC, it was not clear to what extent the increased viscosity associated with CMC, or the concurrent infection with enterotoxigenic<jats:italic>E. coli<\/jats:italic>, was responsible for the increased proliferation of<jats:italic>B. pilosicoli<\/jats:italic>. In a second experiment, five pigs that were weaned onto an R diet were transferred onto R+CMC 3 weeks later. These pigs did not develop a natural infection with enterotoxigenic<jats:italic>E. coli<\/jats:italic>after the diet change, confirming the particular susceptibility of pigs to enterotoxigenic<jats:italic>E. coli<\/jats:italic>proliferation immediately post-weaning.<\/jats:p>","DOI":"10.1079\/bjn2002694","type":"journal-article","created":{"date-parts":[[2003,4,9]],"date-time":"2003-04-09T11:46:34Z","timestamp":1049888794000},"page":"523-532","source":"Crossref","is-referenced-by-count":54,"title":["Increasing the viscosity of the intestinal contents stimulates proliferation of enterotoxigenic<i>Escherichia coli<\/i>and<i>Brachyspira pilosicoli<\/i>in weaner pigs"],"prefix":"10.1017","volume":"88","author":[{"given":"D. E.","family":"Hopwood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. W.","family":"Pethick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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