{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:06:54Z","timestamp":1762016814871},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":1469,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>The composition of the raw legume<jats:italic>Phaseolus vulgaris<\/jats:italic>L. var.<jats:italic>athropurpurea<\/jats:italic>(PhVa) and its effects on the metabolism of young growing rats have been evaluated. The levels of protein, unsaturated fatty acids, carbohydrate, fibre and bioactive factors present in PhVa were comparable with those in other<jats:italic>Phaseolus vulgaris<\/jats:italic>varieties. However, the lectins of PhVa were predominantly of the leucoagglutinating type, and concentrated in the albumin protein fraction. Rats fed a diet (110 g total protein, 16\u00b70 M\/g) in which PhVa meal provided about half of the protein excreted high levels of N in faeces and urine, and grew more slowly, than rats fed a high-quality control diet (<jats:italic>ad libitum<\/jats:italic>or pair-fed). Small intestine, large intestine and pancreas weights were increased (by almost 100 %,<jats:italic>P<\/jats:italic>&lt;0\u00b705), whilst skeletal muscle, thymus and spleen weights were reduced. Blood insulin 16\u00b720<jats:italic>v.<\/jats:italic>0\u00b750 m\/,<jats:italic>P<\/jats:italic>&lt;0\u00b705, thyroxine, glucose, protein (60\u00b75<jats:italic>v.<\/jats:italic>48\u00b73 \/,<jats:italic>P<\/jats:italic>&lt;0\u00b705) and LDL-cholesterol were lowered, whilst glucagon (155\u00b73<jats:italic>v.<\/jats:italic>185\u00b74 n\/,<jats:italic>P<\/jats:italic>&lt;0\u00b705), triiodothyronine and urea were elevated, as were urinary urea, creatinine and glucose. These changes in the local (gut) and systemic metabolism of rats were probably mediated primarily by lectins in PhVa, which were concentrated in the albumin protein fraction, whereas in many other<jats:italic>Phaseolus vulgaris<\/jats:italic>lines they are distributed across the globulin and albumin fractions.<\/jats:p>","DOI":"10.1079\/bjn2002777","type":"journal-article","created":{"date-parts":[[2003,4,9]],"date-time":"2003-04-09T11:46:34Z","timestamp":1049888794000},"page":"311-318","source":"Crossref","is-referenced-by-count":15,"title":["Local (gut) and systemic metabolism of rats is altered by consumption of raw bean (<i>Phaseolus vulgaris<\/i>L. var.<i>athropurpurea<\/i>)"],"prefix":"10.1017","volume":"89","author":[{"given":"Carmen Cavall\u00e9","family":"de Moya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Grant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema","family":"Fr\u00fchbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Urdaneta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencio","family":"Marzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Santidri\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114503000382_ref020","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19950005"},{"key":"S0007114503000382_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(05)80124-1"},{"key":"S0007114503000382_ref018","first-page":"87","volume-title":"Secondary Plant Products: Antinutritional and Beneficial Actions in Animal Feeding","author":"Grant","year":"1999"},{"key":"S0007114503000382_ref035","first-page":"191","volume-title":"Dietary Fibre in Health and Disease","author":"Potter","year":"1995"},{"key":"S0007114503000382_ref010","first-page":"594S","article-title":"Soy consumption and cholesterol reduction: review of animal and human studies","volume":"125","author":"Carroll","year":"1995","journal-title":"Journal of Nutrition"},{"key":"S0007114503000382_ref040","first-page":"717S","article-title":"Saponins as anticarcinogens","volume":"125","author":"Rao","year":"1995","journal-title":"Journal of Nutrition"},{"key":"S0007114503000382_ref002","first-page":"107","volume-title":"Recent Advances of Research in Antinutritional Factors in Legume Seeds and Rapeseed","author":"Ali","year":"1998"},{"key":"S0007114503000382_ref014","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19830039"},{"key":"S0007114503000382_ref037","volume-title":"Plant Lectins","author":"Pusztai","year":"1991"},{"key":"S0007114503000382_ref036","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(99)00242-6"},{"key":"S0007114503000382_ref038","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2740300902"},{"key":"S0007114503000382_ref012","volume-title":"Normas del Codex prote.nas vegetales y directrices generales para la utilizacio protuctos prote\u00ednicos vegetales (PPV) en los alimentos (Codex for vegetable proteins and directions to the use of vegetable proteins for feeding)","year":"1990"},{"key":"S0007114503000382_ref031","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0022-2275(20)39701-7","article-title":"Hepatic production of very low density lipoprotein, catabolism of low density lipoprotein, biliary lipid secretion, and bile salt synthesis in rats fed a bean (Phaseolus vulgaris) diet","volume":"34","author":"Marzolo","year":"1993","journal-title":"Journal of Lipid Research"},{"key":"S0007114503000382_ref017","first-page":"71","volume-title":"Secondary Plant Products: Antinutritional and Beneficial Actions in Animal Feeding","author":"Grant","year":"1999"},{"key":"S0007114503000382_ref011","unstructured":"Carvalho A de FFU (1992) Dietary kidney bean lectins affect insulin levels, change gene expression and modulate metabolism. 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