{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T16:55:26Z","timestamp":1760979326226},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":1163,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>Antioxidant vitamins have been reported to be associated with an improvement in blood lipid profiles, but results are not consistent. The present study was designed to determine whether long-term vitamin C supplementation could alter serum lipid concentrations in subjects who completed a 5-year population-based double-blind intervention trial. A total of 439 Japanese subjects with atrophic gastritis initially participated in the trial using vitamin C and \u03b2-carotene to prevent gastric cancer. Before and upon early termination of \u03b2-carotene supplementation, 134 subjects dropped out of the trial; finally, 161 subjects assigned to the high-dose group (500 mg vitamin C\/d) and 144 subjects assigned to the low-dose group (50 mg vitamin C\/d) were studied. No favourable effect of vitamin C supplementation on serum concentrations of total cholesterol, HDL- and LDL-cholesterol, and triacylglycerol was observed, although high-dose vitamin C supplementation increased serum vitamin C concentrations substantially. Among women, the mean change in serum triacylglycerol decreased (\u22120\u00b712 mmol\/l, 95 % CI \u22120\u00b732, 0\u00b709) in the high-dose group, but increased (+0\u00b712 mmol\/l, 95 % CI 0\u00b703, 0\u00b722) in the low-dose group. In addition, the mean change in serum triacylglycerol among women with hypertriacylglycerolaemia was statistically significant (\u22121\u00b721, 95 % CI \u22122\u00b738, \u22120\u00b705) after high-dose vitamin C supplementation. The 5-year vitamin C supplementation had no markedly favourable effects on the serum lipid and lipoprotein profile. However, our present results do not preclude the possibility that vitamin C supplementation may decrease triacylglycerol concentrations among women with hypertriacylglycerolaemia.<\/jats:p>","DOI":"10.1079\/bjn20031024","type":"journal-article","created":{"date-parts":[[2004,1,27]],"date-time":"2004-01-27T23:51:23Z","timestamp":1075247483000},"page":"81-90","source":"Crossref","is-referenced-by-count":16,"title":["Long-term vitamin C supplementation has no markedly favourable effect on serum lipids in middle-aged Japanese subjects"],"prefix":"10.1017","volume":"91","author":[{"given":"Mi 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