{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:24:12Z","timestamp":1791401052731,"version":"4.3.3"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":1224,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>The present study was designed to evaluate the differential effects of dietary glucose, lactose and starch on small-intestinal morphology, organ weights, pH of chyme and haptoglobin levels in blood plasma of weaned piglets. It was hypothesised that lactose consumption would ameliorate the weaning-induced decrease in gut integrity. A total of forty-two barrows were used. Piglets were weaned at 27 (sd 0\u00b78) d of age and weighed 8\u00b70 (sd 0\u00b751) kg. On the day before weaning (day \u22121) all pigs were blocked according to body weight and randomly assigned to seven groups (<jats:italic>n<\/jats:italic> 6 per group). The groups differed in diet and day of dissection. On the day of weaning, dissection was performed on one group of six piglets. The remaining groups were fed one of three experimental diets in which glucose, lactose or starch had been iso-energetically exchanged, supplying 24% dietary energy. The piglets received a liquid diet (air-dry meal:water of 1:2, w\/w). The piglets were given access to a maximum of dietary energy in order to prevent confounding between feed intake and villus architecture. The piglets were dissected and sampled on days 0, 3, or 10 post-weaning. The results show that the carbohydrate source did not affect growth performance, organ weights, villus architecture, pH of chyme and plasma haptoglobin level. The weaning transition resulted in decreased villus height and increased haptoglobin levels. In the contents of the caecum and large intestine, the pH decreased after weaning. It is concluded that at least under conditions of similar feed intake and low infectious pressure, dietary lactose does not ameliorate the weaning-induced compromise of small-intestinal integrity when compared with either glucose or starch.<\/jats:p>","DOI":"10.1079\/bjn2003981","type":"journal-article","created":{"date-parts":[[2003,11,6]],"date-time":"2003-11-06T17:17:57Z","timestamp":1068139077000},"page":"907-913","source":"Crossref","is-referenced-by-count":36,"title":["Villus height and gut development in weaned piglets receiving diets containing either glucose, lactose or starch"],"prefix":"10.1017","volume":"90","author":[{"given":"M. A. M.","family":"Vente-Spreeuwenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M. A. J.","family":"Verdonk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. W. A.","family":"Verstegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Beynen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114503002034_ref002","volume-title":"Chemical Composition, Digestibility and Feeding Value of Feedstuffs (in Dutch)","year":"2000"},{"key":"S0007114503002034_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5288(93)90038-H"},{"key":"S0007114503002034_ref018","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1986.250.2.C191"},{"key":"S0007114503002034_ref028","unstructured":"Van Beers-Schreurs H (1996) The changes in the function of the large intestine of weaned pigs. PhD thesis, University of Utrecht, The Netherlands."},{"key":"S0007114503002034_ref003","first-page":"3","volume-title":"The Lactating Sow","author":"Darragh","year":"1998"},{"key":"S0007114503002034_ref022","volume-title":"Nutrient Requirements of Swine","year":"1998"},{"key":"S0007114503002034_ref030","first-page":"332","volume-title":"Digestive Physiology of Pigs","author":"Verdonk","year":"2001"},{"key":"S0007114503002034_ref033","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.9.2336"},{"key":"S0007114503002034_ref010","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.1998.285"},{"key":"S0007114503002034_ref015","doi-asserted-by":"publisher","DOI":"10.2527\/jas1975.4061077x"},{"key":"S0007114503002034_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S0377-8401(01)00287-5"},{"key":"S0007114503002034_ref008","unstructured":"Hiss S (2001) Entwicklung und Validierung von enzyimmunologischen Messverfahren zur Bestimmung von Haptoglobin bei verschiedenen Haustierspezies und erste Anwendungen in Pilotstudien (in German). PhD thesis, Hannover, Germany."},{"key":"S0007114503002034_ref007","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0034-5288(18)30541-1","article-title":"Attempts to modify changes in the piglet small intestine after weaning","volume":"40","author":"Hampson","year":"1986","journal-title":"Res Vet Sci"},{"key":"S0007114503002034_ref024","doi-asserted-by":"publisher","DOI":"10.1017\/S1357729800014429"},{"key":"S0007114503002034_ref001","unstructured":"Bruininx EMAM (2002) Individually measured feed intake characteristics in group-housed weanling pigs. PhD thesis, University of Utrecht, The Netherlands."},{"key":"S0007114503002034_ref005","volume-title":"The Living Gut","author":"Ewing","year":"1994"},{"key":"S0007114503002034_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(95)05527-4"},{"key":"S0007114503002034_ref013","first-page":"537","volume-title":"Proceedings of the 10th International Congress of Animal Hygiene","author":"Knura","year":"2000"},{"key":"S0007114503002034_ref034","first-page":"273","volume-title":"Principles of Enzymology for the Food Sciences","author":"Whitaker","year":"1994"},{"key":"S0007114503002034_ref012","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19910079"},{"key":"S0007114503002034_ref014","doi-asserted-by":"publisher","DOI":"10.22358\/jafs\/68115\/2000"},{"key":"S0007114503002034_ref017","unstructured":"Makkink CA (1993) Of piglets, dietary proteins and pancreatic proteases. PhD thesis, University of Wageningen, The Netherlands."},{"key":"S0007114503002034_ref029","unstructured":"Van Dijk A (2001) Spray-dried animal plasma in the diet of weanling piglets: influence on growth performance and underlying mechanisms. PhD thesis, University of Utrecht, The Netherlands."},{"key":"S0007114503002034_ref009","first-page":"61","volume-title":"Production Diseases in Farm Animals, Proceedings of the 11th International Conference","author":"Hiss","year":"2001"},{"key":"S0007114503002034_ref031","first-page":"347","volume-title":"Digestive Physiology of Pigs","author":"Verdonk","year":"2001"},{"key":"S0007114503002034_ref026","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.5.1520"},{"key":"S0007114503002034_ref027","first-page":"152","article-title":"The effect of carbohydrate source on intestinal morphology of weaned pigs","volume":"80","author":"Spreeuwenberg","year":"2002","journal-title":"J Anim Sci"},{"key":"S0007114503002034_ref023","doi-asserted-by":"publisher","DOI":"10.4141\/cjas76-070"},{"key":"S0007114503002034_ref011","unstructured":"Kamphues J (1987) Untersuchungen zu Verdauungsvorg\u00e4ngen bei Absetzferkeln in Abh\u00e4ngigkeit von Futtermenge und \u2013zubereitung sowie van Futterzus\u00e4tzen (In German). PhD thesis, Tier\u00e4rztliche Hochschule Hannover, Germany."},{"key":"S0007114503002034_ref006","first-page":"72","volume-title":"Production Diseases in Farm Animals, Proceedings of the 10th International Conference","author":"Gruys","year":"1999"},{"key":"S0007114503002034_ref016","first-page":"1","article-title":"Studies of the digestibility of pigs fed dietary sucrose, fructose or glucose","volume":"42","author":"Ly","year":"1992","journal-title":"Arch Anim Nutr"},{"key":"S0007114503002034_ref025","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19870073"},{"key":"S0007114503002034_ref020","unstructured":"Nabuurs MJA (1991) Etiologic and pathogenic studies on postweaning diarrhea. 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