{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:35:50Z","timestamp":1791178550226,"version":"4.1.0"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":1194,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p>The prevalence of malnutrition remains high in many developing countries. However, data relating to the long-term effects of severe malnutrition, specifically, serum levels of biochemical indicators of nutritional status, are still scarce in the literature. Hence the present study aimed to investigate the nutritional, biological and growth status of Senegalese preschool children previously hospitalised for severe malnutrition. The study involved twenty-four 7-year-old children who had suffered from marasmus 5 years earlier, twenty-four siblings living in the same household, and nineteen age-matched children living in the centre of Dakar. The siblings were of similar age to the post-marasmic children. Anthropometry, serum biochemical indicators of nutritional status, growth factors, and haematological and mineral parameters were measured. The prevalence of stunting and wasting was the same in the post-marasmic children as in the siblings. Body-fat and fat-free-mass (FFM) deficits in both groups were corroborated by abnormally low concentrations of transthyretin, osteocalcin, insulin-like growth factor (IGF)-1, and insulin-like growth factor-binding protein (IGFBP)-3. FFM was positively and significantly correlated with concentrations of IGF-1 and IGFBP-3. In the post-marasmic children, height for age was also correlated with IGF-1. Of the post-marasmic children, 53 % had Fe-deficiency anaemia, as did 35 % of the siblings and 29 % of the controls. No significant associations were found between the serum concentrations of Ca, Cu, K, Mg, Na, P, Se, Zn and growth retardation. At 5 years after nutritional rehabilitation, the post-marasmic children remained stunted with nutritional indices significantly lower than the control children. However, these children were doing as well as their siblings except for minor infections.<\/jats:p>","DOI":"10.1079\/bjn2003990","type":"journal-article","created":{"date-parts":[[2003,11,27]],"date-time":"2003-11-27T21:48:27Z","timestamp":1069969707000},"page":"1123-1132","source":"Crossref","is-referenced-by-count":21,"title":["Nutritional status of preschool Senegalese children: long-term effects of early severe malnutrition"],"prefix":"10.1017","volume":"90","author":[{"given":"Nicole","family":"Idohou-Dossou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salimata","family":"Wade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadou T.","family":"Guiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheikh S.","family":"Sarr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babou","family":"Diaham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djibril","family":"Ciss\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Beau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chappuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lemonnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114503002320_ref024","first-page":"115","volume-title":"Folates et Cobalamines: Collection Progr\u00e8s en H\u00e9matologie","author":"Herbert","year":"1987"},{"key":"S0007114503002320_ref046","doi-asserted-by":"publisher","DOI":"10.1542\/peds.83.4.532"},{"key":"S0007114503002320_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.12.2302"},{"key":"S0007114503002320_ref018","first-page":"130","volume-title":"Les Carences Nutritionnelles dans les PVD. 3\u00e8mes Journ\u00e9es du GERM","author":"Gouache","year":"1989"},{"key":"S0007114503002320_ref008","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1651-2227.1988.tb10831.x","article-title":"Osteocalcin in children with short stature","volume":"343","author":"Colle","year":"1988","journal-title":"Acta Paediatr Scand"},{"key":"S0007114503002320_ref039","first-page":"161","article-title":"Adequacy of dietary mineral supply for human bone growth and mineralisation","volume":"48","author":"Prentice","year":"1994","journal-title":"Eur J Clin Nutr"},{"key":"S0007114503002320_ref023","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/33.1.10"},{"key":"S0007114503002320_ref025","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.3.702"},{"key":"S0007114503002320_ref044","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/118.8.1002"},{"key":"S0007114503002320_ref019","first-page":"83","article-title":"Chronic undernutrition and cognitive abilities","volume":"38C","author":"Grantham-McGregor","year":"1984","journal-title":"Hum Nutr Clin Nutr"},{"key":"S0007114503002320_ref002","first-page":"75","article-title":"Nutritional influences on linear growth: a general review","volume":"48","author":"Allen","year":"1994","journal-title":"Eur J Clin Nutr"},{"key":"S0007114503002320_ref021","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/30.8.1286"},{"key":"S0007114503002320_ref028","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.84B5.0840732"},{"key":"S0007114503002320_ref022","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.2.550"},{"key":"S0007114503002320_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(65)90004-2"},{"key":"S0007114503002320_ref014","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198711000-00005"},{"key":"S0007114503002320_ref034","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81538-0"},{"key":"S0007114503002320_ref040","unstructured":"Sarr, CS (1996) Evaluation du devenir d'enfants ayant souffert de malnutritionprot\u00e9ino-\u00e9nerg\u00e9tique s\u00e9v\u00e8re \u00e0 Dakar (r\u00e9sultats pr\u00e9liminaires). 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