{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T12:01:49Z","timestamp":1772020909137,"version":"3.50.1"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":1194,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p>The prevention of arterial thrombotic diseases has a high priority in developed\n                    countries. An inappropriate diet may be an important risk factor for thrombotic\n                    events. The daily intake of an anti-thrombotic diet may offer a convenient and\n                    effective way of prevention. The aim of the present study was to test tomato\n                    extracts for anti-thrombotic effects and to identify those varieties that have\n                    such an effect. A shear-induced platelet-function test (haemostatometry) was\n                    used to test anti-thrombotic potential <jats:italic>in\n                        vitro<\/jats:italic>. Extracts from those tomato varieties that showed a\n                    significant anti-thrombotic activity <jats:italic>in vitro<\/jats:italic>\n                    were further assessed <jats:italic>in vivo<\/jats:italic>, using a\n                    laser-induced thrombosis test in mice. One tomato variety (KG99-4) showed\n                    significant anti-thrombotic activity both <jats:italic>in\n                        vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. KG99-4\n                    inhibited not only platelet-rich thrombus formation but also had a thrombolytic\n                    effect. It is concluded that haemostatometry can detect and classify the\n                    anti-thrombotic potential of fruits and vegetables and offers a simple way of\n                    screening for such effects.<\/jats:p>","DOI":"10.1079\/bjn2003994","type":"journal-article","created":{"date-parts":[[2003,11,27]],"date-time":"2003-11-27T21:48:27Z","timestamp":1069969707000},"page":"1031-1038","source":"Crossref","is-referenced-by-count":44,"title":["Tomatoes have natural anti-thrombotic effects"],"prefix":"10.1017","volume":"90","author":[{"given":"J.","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Taka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Ijiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Naemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Oiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Seki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Suganuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Inakuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114503002228_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91846-M"},{"key":"S0007114503002228_ref017","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.4.922"},{"key":"S0007114503002228_ref024","first-page":"259","volume-title":"Haemostasis and\n                        Thrombosis","author":"Sixma","year":"1994"},{"key":"S0007114503002228_ref011","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200209000-00004"},{"key":"S0007114503002228_ref010","first-page":"43","article-title":"Modelling\n                    coronary thrombosis from nonanticoagulated human blood in vitro","volume":"4","author":"Gorog","year":"1990","journal-title":"Hematol Pathol"},{"key":"S0007114503002228_ref031","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200301000-00007"},{"key":"S0007114503002228_ref025","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.10.1050"},{"key":"S0007114503002228_ref006","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/09537100120058757","article-title":"Effects of\n                    tomato extract on human platelet aggregation in vitro","volume":"12","author":"Dutta-Roy","year":"2001","journal-title":"Platelets"},{"key":"S0007114503002228_ref004","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011090"},{"key":"S0007114503002228_ref020","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.12.2307"},{"key":"S0007114503002228_ref007","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1056\/NEJM199201233260406","article-title":"The\n                    pathogenesis of coronary artery disease and the acute coronary\n                    syndromes","volume":"326","author":"Fuster","year":"1992","journal-title":"N Engl J Med"},{"key":"S0007114503002228_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91277-F"},{"key":"S0007114503002228_ref023","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.12.3592"},{"key":"S0007114503002228_ref009","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1055\/s-0038-1653806","article-title":"Thrombotic\n                    status analyzer. Measurement of platelet-rich thrombus formation and lysis in\n                    native blood","volume":"73","author":"Gorog","year":"1995","journal-title":"Thromb Haemost"},{"key":"S0007114503002228_ref008","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520380049034"},{"key":"S0007114503002228_ref005","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.4.1182"},{"key":"S0007114503002228_ref027","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.12.2467"},{"key":"S0007114503002228_ref018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022095"},{"key":"S0007114503002228_ref012","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.13.1233"},{"key":"S0007114503002228_ref029","first-page":"260","article-title":"Effect of physical training on thrombotic tendency in rats:\n                    decrease in thrombotic tendency measured by the He-Ne laser-induced thrombus\n                    formation method","volume":"19","author":"Yamamoto","year":"1989","journal-title":"Haemostasis"},{"key":"S0007114503002228_ref030","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.47.431"},{"key":"S0007114503002228_ref015","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/91.3.271"},{"key":"S0007114503002228_ref001","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.6.1691S"},{"key":"S0007114503002228_ref021","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.3.1077"},{"key":"S0007114503002228_ref003","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.10.2619"},{"key":"S0007114503002228_ref014","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.1.53"},{"key":"S0007114503002228_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(75)90025-4"},{"key":"S0007114503002228_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.1.93"},{"key":"S0007114503002228_ref013","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-12-200106190-00010"},{"key":"S0007114503002228_ref026","doi-asserted-by":"publisher","DOI":"10.1080\/0953371027000-1"},{"key":"S0007114503002228_ref019","doi-asserted-by":"publisher","DOI":"10.1080\/09537100020027833"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114503002228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T02:28:00Z","timestamp":1660184880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114503002228\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["S0007114503002228"],"URL":"https:\/\/doi.org\/10.1079\/bjn2003994","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}