{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T01:56:49Z","timestamp":1725415009742},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":889,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p>The present study compared leucine kinetics and acute-phase-protein concentrations in three groups of marasmic, acutely infected Malawian children fed one of three isoenergetic diets. These were: an enhanced-protein-quality diet (egg-white+tryptophan, providing 1.2 g protein\/kg per d;<jats:italic>n<\/jats:italic>14); an increased-protein-content diet (egg-white+tryptophan, providing 1\u00b78 g protein\/kg per d;<jats:italic>n<\/jats:italic>14); a standard-protein diet (1\u00b72 g milk protein\/kg per d;<jats:italic>n<\/jats:italic>25). The hypotheses tested were that children receiving a diet with more protein would have greater rates of non-oxidative leucine disposal and that children receiving an isonitrogenous diet with a higher protein quality would have lower rates of leucine oxidation. The children were studied after 24 h of therapy using standard [<jats:sup>13<\/jats:sup>C]leucine stable-isotope tracer techniques. The children receiving the higher-protein-content diet had greater leucine kinetic rates than those receiving the standard-protein-content diet; non-oxidative leucine disposal was 170 (SD 52)<jats:italic>v.<\/jats:italic>122 (SD 30) \u03bcmol leucine\/kg per h (<jats:italic>P<\/jats:italic>&lt;0\u00b701). Leucine oxidation was less in the children receiving the enhanced-protein-quality diet than in those receiving the standard-protein-quality diet; 34 (SD 12)<jats:italic>v.<\/jats:italic>45 (SD 13) \u03bcmol leucine\/kg per h (<jats:italic>P<\/jats:italic>&lt;0\u00b705). The children receiving the high-protein-content diet increased their serum concentration for five of six acute-phase proteins 24 h after starting therapy, while those receiving the standard-protein-content diet did not. These data suggest that there was greater whole-body protein synthesis, and a more vigorous acute-phase response associated with the higher-protein-content diet. The clinical benefits associated with a higher protein intake in marasmic, acutely infected children need further study.<\/jats:p>","DOI":"10.1079\/bjn20041242","type":"journal-article","created":{"date-parts":[[2004,11,3]],"date-time":"2004-11-03T02:41:24Z","timestamp":1099449684000},"page":"589-595","source":"Crossref","is-referenced-by-count":11,"title":["Protein quantity, not protein quality, accelerates whole-body leucine kinetics and the acute-phase response during acute infection in marasmic Malawian children"],"prefix":"10.1017","volume":"92","author":[{"given":"M. J.","family":"Manary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. E.","family":"Yarasheski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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