{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:07:06Z","timestamp":1770502026648,"version":"3.49.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"S1","license":[{"start":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T00:00:00Z","timestamp":1173312000000},"content-version":"unspecified","delay-in-days":706,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p>The rationale for supplementing an infant formula with prebiotics is to obtain a bifidogenic effect and the implied advantages of a \u2018breast-fed-like\u2019 flora. So far, the bifidogenic effect of oligofructose and inulin has been demonstrated in animals and in adults, of oligofructose in infants and toddlers and of a longchain inulin (10 %) and galactooligosaccharide (90 %) mixture in term and preterm infants. The addition of prebiotics to infant formula softens stools but other putative effects remain to be demonstrated. Studies published post marketing show that infants fed a long-chain inulin\/galactooligosaccharide mixture (0\u00b78 g\/dl) in formula grow normally and have no side-effects. The addition of the same mixture at a concentration of 0\u00b78 g\/dl to infant formula was therefore recognized as safe by the European Commission in 2001 but follow-up studies were recommended. It is thought that a bifidogenic effect is beneficial for the infant host. The rising incidence in allergy during the first year of life may justify the attempts to modulate the infant's flora. Comfort issues should not be confused with morbidity and are likely to be multifactorial. The functional effects of prebiotics on infant health need further study in controlled intervention trials.<\/jats:p>","DOI":"10.1079\/bjn20041354","type":"journal-article","created":{"date-parts":[[2005,5,4]],"date-time":"2005-05-04T06:25:26Z","timestamp":1115187926000},"page":"S57-S60","source":"Crossref","is-referenced-by-count":35,"title":["Application of prebiotics in infant foods"],"prefix":"10.1017","volume":"93","author":[{"given":"Gigi","family":"Veereman-Wauters","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,8]]},"reference":[{"key":"S0007114505000814_ref006","first-page":"521","article-title":"Improved humoral immune response to measles vaccine in infants receiving infant cereal with fructo-oligosaccharides","volume":"31","author":"Firmansyah","year":"2001","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"S0007114505000814_ref021","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.2.406s"},{"key":"S0007114505000814_ref017","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200203000-00014"},{"key":"S0007114505000814_ref016","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2003950"},{"key":"S0007114505000814_ref005","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.4.937"},{"key":"S0007114505000814_ref002","doi-asserted-by":"publisher","DOI":"10.1136\/fn.86.3.F178"},{"key":"S0007114505000814_ref020","first-page":"402","article-title":"Clinical evaluation in term infants of a new formula based on pre-biotics, \u03b2-palmitate, and hydrolised proteins","volume":"32","author":"Rigo","year":"2001","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"S0007114505000814_ref012","first-page":"399","article-title":"Stimulation of endogenous Bifidobacteria in term infants by an infant formula containing prebiotics","volume":"32","author":"Knol","year":"2001","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"S0007114505000814_ref025","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200303000-00008"},{"key":"S0007114505000814_ref008","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1093\/jn\/125.6.1401","article-title":"Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics","volume":"125","author":"Gibson","year":"1995","journal-title":"J Nutr"},{"key":"S0007114505000814_ref022","doi-asserted-by":"publisher","DOI":"10.1079\/BJN\/2002543"},{"key":"S0007114505000814_ref007","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114741"},{"key":"S0007114505000814_ref009","first-page":"252","article-title":"Effect of 3 doses of fructo-oligosaccharides in infants","volume":"31","author":"Guesry","year":"2000","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"S0007114505000814_ref015","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1651-2227.2003.tb00649.x","article-title":"Prebiotics in infant milk formulas: new perspectives","volume":"441","author":"Miniello","year":"2003","journal-title":"Acta Paediatr Suppl"},{"key":"S0007114505000814_ref011","doi-asserted-by":"publisher","DOI":"10.1007\/s001120170011"},{"key":"S0007114505000814_ref018","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1651-2227.2003.tb00650.x","article-title":"Effects of a new mixture of prebiotics on faecal flora and stools in term infants","volume":"441","author":"Moro","year":"2003","journal-title":"Acta Paediatr Suppl"},{"key":"S0007114505000814_ref013","first-page":"477","article-title":"Bifidobacterial species that are present in breast-fed infants are stimulated in formula fed infants by changing to a formula containing prebiotics","volume":"34","author":"Knol","year":"2002","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"S0007114505000814_ref024","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199910000-00121"},{"key":"S0007114505000814_ref003","doi-asserted-by":"publisher","DOI":"10.1080\/09637480120092080"},{"key":"S0007114505000814_ref001","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118130"},{"key":"S0007114505000814_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91708-6"},{"key":"S0007114505000814_ref014","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1651-2227.2003.tb00651.x","article-title":"Pro- and pre-biotics administration in preterm infants: colonization and influence on faecal flora","volume":"441","author":"Marini","year":"2003","journal-title":"Acta Paediatr Suppl"},{"key":"S0007114505000814_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(03)00063-7"},{"key":"S0007114505000814_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(02)00463-5"},{"key":"S0007114505000814_ref027","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199910000-00084"},{"key":"S0007114505000814_ref010","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200001000-00019"},{"key":"S0007114505000814_ref026","first-page":"566","article-title":"Introduction of solid weaning foods with added prebiotic oligosaccharides affect the composition of the intestinal microflora","volume":"36","author":"Scholtens","year":"2003","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"S0007114505000814_ref028","doi-asserted-by":"publisher","DOI":"10.1079\/BJN\/2002551"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114505000814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T15:54:49Z","timestamp":1706198089000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114505000814\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":28,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0007114505000814"],"URL":"https:\/\/doi.org\/10.1079\/bjn20041354","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}