{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T14:53:06Z","timestamp":1724511186760},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T00:00:00Z","timestamp":1173312000000},"content-version":"unspecified","delay-in-days":676,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p>Diet is known to modulate the development of diabetes in diabetes-prone BioBreeding (BBdp) rats. The objective of the present study was to determine the effect of fermentable fibre (FF) on immune function in BBdp and diabetes-resistant BioBreeding (BBdr) rats after weaning. Weanling BBdp (thirty-six to thirty-eight per diet) and BBdr rats (thirty to thirty-two per diet) were fed a nutritionally complete, semi-purified, casein-based diet containing either cellulose (control diet, 8 % w\/w) or FF (3\u00b72 % cellulose+4\u00b78 % w\/w inulin). At 35 d, the small intestine was excised and lymphocytes isolated from spleen, mesenteric lymph nodes and Peyer's patches. Feeding FF to both BBdr and BBdp rats affected the production of anti-inflammatory cytokines (<jats:italic>P<\/jats:italic>=0\u00b702). In BBdr rats, feeding FF compared with cellulose resulted in an increased small intestinal length (<jats:italic>P<\/jats:italic>=0\u00b70031), higher proliferative (stimulation) index from both splenocytes (<jats:italic>P<\/jats:italic>=0\u00b7001) and mesenteric lymph nodes (<jats:italic>P<\/jats:italic>=0\u00b704), and an increased proportion of CD8+ T-cells in the Peyer's patches (<jats:italic>P<\/jats:italic>=0\u00b7003). We did not observe an effect of diet on the number of IgA-bearing cells in the jejunum from BBdr rats. Feeding FF to BBdp rats did not affect the same parameters. BBdp rats had both a higher proportion of B-cells in the Peyer's patches (<jats:italic>P<\/jats:italic>=0\u00b701) and a higher number of IgA+ cells in the jejunum (<jats:italic>P<\/jats:italic>=0\u00b70036) when fed a diet containing FF, a response not observed in BBdr rats. We demonstrate that several aspects of the BBdp immune system respond differently than that of BBdr rats when challenged at weaning with FF.<\/jats:p>","DOI":"10.1079\/bjn20051408","type":"journal-article","created":{"date-parts":[[2005,6,18]],"date-time":"2005-06-18T15:18:02Z","timestamp":1119107882000},"page":"645-653","source":"Crossref","is-referenced-by-count":10,"title":["Diabetes-prone BioBreeding rats do not have a normal immune response when weaned to a diet containing fermentable fibre"],"prefix":"10.1017","volume":"93","author":[{"given":"RoseMarie","family":"Stillie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda C.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine 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