{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:45:52Z","timestamp":1754484352240},"reference-count":52,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T00:00:00Z","timestamp":1173312000000},"content-version":"unspecified","delay-in-days":584,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p>The incidence of childhood obesity is rising dramatically throughout industrialised countries. To evaluate and study the impact of childhood obesity on lipoprotein metabolism, we developed a new animal model of premature obesity. Yucatan mini-pigs aged 4 months were studied over a 12-month period from childhood to adulthood. Animals were divided into two groups: the first group were overfed a Western misbalanced diet; the second group were normally fed a recommended human-type diet. Cholesterol and triacylglycerol concentrations in VLDL-, LDL- and HDL-lipoproteins were followed from baseline to adulthood by fast protein liquid chromatography. At 10 (the end of sexual maturation) and 16 months old (adulthood), liver, visceral and subcutaneous adipose tissues were sampled. Real-time RT-PCR was performed in order to compare apo AI, apo B, apo C-III, PPAR-\u03b1, insulin receptor and lipoprotein lipase gene expression between groups and ages. Differences between groups were observed only after sexual maturity. Adult overfed mini-pigs had a higher LDL-cholesterol:HDL-cholesterol ratio (<jats:italic>P<\/jats:italic>&lt;0\u00b705; 0\u00b755 (SE 0\u00b706) for overfed<jats:italic>v<\/jats:italic>. 0\u00b742 (SE 0\u00b704) for normally fed pigs at the tenth month of the study). In both groups, VLDL-triacylglycerol decreased (<jats:italic>P<\/jats:italic>&lt;0\u00b705). VLDL-triacylglycerol evolution in the overfed group was associated with an increase in LDL-triacylglycerol plasma concentrations (<jats:italic>P<\/jats:italic>&lt;0\u00b705) after sexual maturation. LDL-triacylglycerol concentration in overfed mini-pigs went from an average of 0\u00b728 mmol\/l before sexual maturation to reach an average concentration of 0\u00b756 mmol\/l afterwards. This phenomenon has never been observed in similar studies when obesity is induced in adult mini-pigs and may represent a specific hallmark of an obesity induced during sexual maturity.<\/jats:p>","DOI":"10.1079\/bjn20051478","type":"journal-article","created":{"date-parts":[[2005,8,23]],"date-time":"2005-08-23T07:23:37Z","timestamp":1124781817000},"page":"282-289","source":"Crossref","is-referenced-by-count":9,"title":["Obesity induced during sexual maturation is linked to LDL-triacylglycerols in Yucatan miniature swine"],"prefix":"10.1017","volume":"94","author":[{"given":"Sylvain 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