{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:32:17Z","timestamp":1787005937345,"version":"build-2736575974"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T00:00:00Z","timestamp":1173312000000},"content-version":"unspecified","delay-in-days":492,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p>The purpose of the present study was to clarify the manner by which the supplementation of high-P diet induces bone loss. Eighteen 4-week-old male Wistar-strain rats were assigned randomly to three groups and fed diets containing three P levels (0\u00b73, 0\u00b79, and 1\u00b75%) for 21d. A lower serum Ca concentration was observed in the rats fed on the 1\u00b75% P diet than in the other two groups. Serum P and parathyroid hormone concentrations and urinary excretion of C-terminal telopeptide of type I collagen were elevated with increasing dietary P levels. Serum osteocalcin concentration was increased in the rats fed on the 1\u00b75% P diet than in the other two groups. Bone formation rate of the lumbar vertebra was significantly increased in the two high-P groups than in the 0\u00b73% P group. Osteoclast number was significantly increased with increasing dietary P levels. Bone mineral content and bone mineral density of the femur and lumbar vertebra and ultimate compression load of the lumbar vertebra were decreased with increasing dietary P levels. Additionally, ultimate bending load of the femur was decreased in the rats fed on the 1\u00b75% P diet than in the other two groups. Receptor activator of NF-\u03baB ligand (RANKL) mRNA expression in the femur was significantly higher with increasing dietary P levels. These results suggest that secondary hyperparathyroidism due to a high-P diet leads to bone loss via an increase in bone turnover. Furthermore, an increase in osteoclast number was caused by increased RANKL mRNA expression.<\/jats:p>","DOI":"10.1079\/bjn20051552","type":"journal-article","created":{"date-parts":[[2005,11,3]],"date-time":"2005-11-03T16:13:38Z","timestamp":1131034418000},"page":"666-674","source":"Crossref","is-referenced-by-count":19,"title":["High-phosphorus diet stimulates receptor activator of nuclear factor-\u03baB ligand mRNA expression by increasing parathyroid hormone secretion in 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