{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:43:33Z","timestamp":1777862613721,"version":"3.51.4"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T00:00:00Z","timestamp":1173312000000},"content-version":"unspecified","delay-in-days":372,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p>The reversibility of osteopenia secondary to isolated Ca deficiency (CaDef) is still not clear. We studied the effect of severe CaDef on Ca homeostasis and bone accrual in a \u2018hypercalcaemic\u2019 animal, the rabbit, during the post-weaning period and its reversibility on Ca supplementation. Male Belgian 5-week-old rabbit pups were fed CaDef diet (0\u00b7026% Ca) for 10 weeks. As compared with those fed with a normal chow diet (0\u00b745% Ca), CaDef pups developed significant hypocalcaemia (<jats:italic>P<\/jats:italic>&lt;0\u00b705), hypocalciuria (urinary Ca 76 (sem 12) <jats:italic>V<\/jats:italic> 17 (sem 1) mg\/l;<jats:italic>P<\/jats:italic>&lt;0\u00b7005), hypophosphataemia (serum inorganic P 100 (sem 6) <jats:italic>V.<\/jats:italic> 65 (sem 4) mg\/l; <jats:italic>P<\/jats:italic>&lt;0\u00b7005), secondary hyperparathyroidism (SHPT) (serum intact parathyroid hormone human equivalent 18\u00b72 (sem 1\u00b74) <jats:italic>V.<\/jats:italic> 125\u00b70 (sem 4\u00b75) pg\/ml; <jats:italic>P<\/jats:italic>&lt;0\u00b7001) and elevated serum calcitriol levels (34\u00b70 (sem 3\u00b79) <jats:italic>V.<\/jats:italic> 91\u00b70 (sem 1\u00b70) pg\/ml; <jats:italic>v<\/jats:italic>&lt;0\u00b7005). Elevated urinary C-terminal telopeptide of class I collagen (<jats:italic>P<\/jats:italic>&lt;0\u00b7005) and total serum alkaline phosphatase (<jats:italic>P<\/jats:italic>&lt;0\u00b7005) suggested increased bone turnover. There was a significantly lower gain in bone mineral density (BMD) and bone mineral content (BMC) in the whole body and lumbar spine <jats:italic>in vivo<\/jats:italic>, and various sub-regions of the femur and tibia <jats:italic>in vitro<\/jats:italic>.Supplementation of adequate Ca (0\u00b745% Ca) after 15 weeks on the normal diet resulted in rapid catch-up growth, and resolution of SHPT. Rapid gain in various BMD and BMC parameters continued at 30 weeks of age, and both were comparable with those in rabbits on a normal diet. We conclude that Ca deficiency-induced SHPT and poor bone accrual in growing rabbit pups are rapidly reversible with Ca supplementation. The present study indicates that early intervention may be a more appropriate window period for human nutritional corrective measures.<\/jats:p>","DOI":"10.1079\/bjn20051656","type":"journal-article","created":{"date-parts":[[2006,2,28]],"date-time":"2006-02-28T00:06:47Z","timestamp":1141085207000},"page":"582-590","source":"Crossref","is-referenced-by-count":11,"title":["Calcium deficiency-induced secondary hyperparathyroidism and osteopenia are rapidly reversible with calcium supplementation in growing rabbit pups"],"prefix":"10.1017","volume":"95","author":[{"given":"Meenal","family":"Mehrotra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushil K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishan","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep 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