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Larvae were fed a control diet except during three different periods (period A: from 8 to 13d post-hatching (dph); period B: from 13 to 18dph; period C: from 18 to 23dph) with two compound diets containing high levels of vitamin A or PUFA. European sea bass morphogenesis was affected by these two dietary nutrients during the early stages of development. The genes involved in morphogenesis could be modulated between 8 and 13dph, and our results indicated that retinoids and fatty acids influenced two different molecular pathways that in turn implicated two different gene cascades, resulting in two different kinds of malformation. Hypervitaminosis A delayed development, reducing the number of vertebral segments and disturbing bone formation in the cephalic region. These malformations were correlated to an upregulation of retinoic acid receptor \u03b3, retinoid X receptor (RXR) \u03b1 and bone morphogenetic protein (BMP)4. An excess of PUFA accelerated the osteoblast differentiation process through the upregulation of RXR\u03b1 and BMP4, leading to a supernumerary vertebra. These results suggest that the composition of diets devoted to marine fish larvae has a particularly determining effect before 13dph on the subsequent development of larvae and juvenile fish.<\/jats:p>","DOI":"10.1079\/bjn20051668","type":"journal-article","created":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T21:40:01Z","timestamp":1143668401000},"page":"677-687","source":"Crossref","is-referenced-by-count":100,"title":["Intake of high levels of vitamin A and polyunsaturated fatty acids during different developmental periods modifies the expression of morphogenesis genes in European sea bass (<i>Dicentrarchus labrax<\/i>)"],"prefix":"10.1017","volume":"95","author":[{"given":"Laure A. 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