{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:24:54Z","timestamp":1770506694262,"version":"3.49.0"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T00:00:00Z","timestamp":1173312000000},"content-version":"unspecified","delay-in-days":341,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p>The effects of six balanced diets for 3 weeks on dietary intake, growth, liver weight and fat, plasma cholesterol, total antioxidant capacity, liver glutathione status and antioxidant enzymes in growing male Wistar rats were studied. Ten rats per group were fed casein- and soyabean-based diets with or without 2\u00b74% cholesterol-raising agent. Seven percent of the diet consisted of a cellulose\u2013wheat starch mix (35:65; control diets), freeze-dried nori (nori diets) or konbu (konbu diets). The 7% dietary supplement of seaweeds was well accepted and induced normal growth rates in rats. Except for food intake, total and reduced glutathione and total antioxidant capacity, dietary cholesterol addition significantly affected (at least<jats:italic>P<\/jats:italic>&lt;0\u00b705) all parameters studied. Alga consumption affected total and reduced glutathione, glutathione reductase activity, plasma cholesterol, and total and cholesterol-adjusted total antioxidant capacity (at least<jats:italic>P<\/jats:italic>&lt;0\u00b705). A significant cholesterol\u2013alga interaction was found for liver weight, total glutathione peroxidase (GSH-Px) and the Se-dependent GSH-Px:total GSH-Px ratio (at least<jats:italic>P<\/jats:italic>&lt;0\u00b705). GSH-Px activity increased in cholesterol-fed nori rats mainly as Se-dependent GSH-Px, while in konbu and control groups the GSH-Px activity was related to increases in both non-Se-dependent and Se-dependent GSH-Px activities. The decrease in the antioxidant status of konbu rats was related to the high As content of this alga, which led to a compensatory increase in glutathione reductase activity in these animals. In conclusion, although some antioxidant compounds are present in algae, other dietary compounds, such as As, induced poor antioxidant status in rats.<\/jats:p>","DOI":"10.1079\/bjn20051682","type":"journal-article","created":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T21:40:01Z","timestamp":1143668401000},"page":"696-702","source":"Crossref","is-referenced-by-count":36,"title":["Differential effects of konbu and nori seaweed dietary supplementation on liver glutathione status in normo- and hypercholesterolaemic growing rats"],"prefix":"10.1017","volume":"95","author":[{"given":"Ar\u00e1nzazu","family":"Bocanegra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juana","family":"Benedu\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"S\u00e9 nchez-Muniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,8]]},"reference":[{"key":"S0007114506000912_ref025","doi-asserted-by":"publisher","DOI":"10.1042\/cs0840407"},{"key":"S0007114506000912_ref026","first-page":"85","volume-title":"Guide for the Care and Use of Laboratory Animals","year":"1985"},{"key":"S0007114506000912_ref038","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-6618(03)00103-8"},{"key":"S0007114506000912_ref033","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s002170000264","article-title":"Dietary fiber and physicochemical properties of edible Spanish seaweeds","volume":"212","author":"Rup\u00e9rez","year":"2001","journal-title":"Eur Food Res Technol"},{"key":"S0007114506000912_ref032","first-page":"10","article-title":"An\u00e1lisis elemental de algas por ICPAES (Elemental analysis of algae for ICP-AES)","volume":"1","author":"R\u00f3denas de la Rocha","year":"2002","journal-title":"Schironia"},{"key":"S0007114506000912_ref029","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1998.3915"},{"key":"S0007114506000912_ref024","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2004.11.094"},{"key":"S0007114506000912_ref023","doi-asserted-by":"publisher","DOI":"10.1080\/01635589109514130"},{"key":"S0007114506000912_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(00)00083-8"},{"key":"S0007114506000912_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(76)90747-6"},{"key":"S0007114506000912_ref018","first-page":"163","volume-title":"Influence of dietary fibre on cholesterol metabolism in experimental animals","author":"Kritchevsky","year":"1993"},{"key":"S0007114506000912_ref017","doi-asserted-by":"publisher","DOI":"10.3136\/nskkk1962.37.7_559"},{"key":"S0007114506000912_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(00)00149-4"},{"key":"S0007114506000912_ref014","first-page":"612","article-title":"Quality factors and functional components in the edible seaweeds. I. Distribution on n-3 fatty acids in 10 species of seaweeds by their habitats","volume":"22","author":"Jeong","year":"1993","journal-title":"J Korean Soc Food Nutr"},{"key":"S0007114506000912_ref013","first-page":"451","volume-title":"In Proceeding of The Seventh International Seaweed Symposium","author":"Ito","year":"1972"},{"key":"S0007114506000912_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S0043-1354(99)00120-7"},{"key":"S0007114506000912_ref034","doi-asserted-by":"publisher","DOI":"10.1016\/0271-5317(95)02065-9"},{"key":"S0007114506000912_ref002","doi-asserted-by":"publisher","DOI":"10.1139\/y59-099"},{"key":"S0007114506000912_ref039","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2003.09.015"},{"key":"S0007114506000912_ref009","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-001-0716-6"},{"key":"S0007114506000912_ref031","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/120.6.602"},{"key":"S0007114506000912_ref027","doi-asserted-by":"publisher","DOI":"10.1002\/tox.10129"},{"key":"S0007114506000912_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(80)90139-6"},{"key":"S0007114506000912_ref030","doi-asserted-by":"publisher","DOI":"10.1081\/ESE-120016894"},{"key":"S0007114506000912_ref037","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(99)00108-6"},{"key":"S0007114506000912_ref035","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.7.2302"},{"key":"S0007114506000912_ref021","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"S0007114506000912_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(03)00141-8"},{"key":"S0007114506000912_ref006","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00431-002-1113-7","article-title":"Serious adverse effects of unconventional therapies for children and adolescents: a systematic review of recent evidence","volume":"162","author":"Ernst","year":"2003","journal-title":"Eur J Ped"},{"key":"S0007114506000912_ref004","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/126.12.3032"},{"key":"S0007114506000912_ref019","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2740540410"},{"key":"S0007114506000912_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-2244(99)00015-1"},{"key":"S0007114506000912_ref015","first-page":"114","article-title":"Evaluaci\u00f3n nutricional y efectos fisiol\u00f3gicos de macroalgas marinas comestibles (Nutritional evaluation and physiological effects of edible marine algae)","volume":"49","author":"Jim\u00e9nez-Escrig","year":"1999","journal-title":"Arch Latinoam Nutr"},{"key":"S0007114506000912_ref028","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"J Lab Clin Med"},{"key":"S0007114506000912_ref005","unstructured":"Ergueta Mart\u00ednez A An\u00e1lisis elemental de algas empleadas en alimentaci\u00f3n, mediante espectrometr\u00edas ICP. PhD Thesis, Facultad de Farmacia, Universidad Complutense de Madrid. (2001)"},{"key":"S0007114506000912_ref011","first-page":"79","article-title":"Metals in Ulva lactuca in Hong Kong intertidal waters","volume":"47","author":"Ho","year":"1990","journal-title":"Bull Mar Sci"},{"key":"S0007114506000912_ref036","doi-asserted-by":"publisher","DOI":"10.1177\/1082013203038860"},{"key":"S0007114506000912_ref001","doi-asserted-by":"publisher","DOI":"10.1042\/bj2720247"},{"key":"S0007114506000912_ref012","first-page":"167","article-title":"Antioxidant activity of selected commercial eaweeds","volume":"8","author":"Ismail","year":"2002","journal-title":"Mal J Nutr"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114506000912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,25]],"date-time":"2021-07-25T07:16:00Z","timestamp":1627197360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114506000912\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0007114506000912"],"URL":"https:\/\/doi.org\/10.1079\/bjn20051682","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}