{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:27:17Z","timestamp":1791394037748,"version":"4.3.3"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T00:00:00Z","timestamp":1173312000000},"content-version":"unspecified","delay-in-days":219,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>Taurine deficiency in patients on long-term parenteral nutrition may be involved in cholestasis. We aimed to assess plasma taurine and tauro-conjugated bile acids in adults with short-bowel syndrome and their response to intravenous taurine. Thirty-two adult patients, who had been on taurine-free parenteral nutrition for a mean of 59(SE14) months for short-bowel syndrome, were studied retrospectively. In a second study, a subgroup of ten patients with chronic cholestasis received taurine-enriched (6\u00b70(SE0\u00b76)mg\/kg per d) parenteral nutrition for 55(SE13) months. Post-absorptive plasma taurine and bile acid concentrations were measured and liver function tests routinely sampled. At baseline, plasma taurine was lower in patients with a jejunal length of less than 35cm (group A,<jats:italic>n<\/jats:italic>16) than in those with a jejunal length of 35cm or more (group B,<jats:italic>n<\/jats:italic>16): 43(SE3)<jats:italic>v<\/jats:italic>. 58(SE4)\u03bcmol\/l (<jats:italic>P<\/jats:italic>=0\u00b701). The groups were no different in terms of chronic cholestasis (1\/6<jats:italic>v<\/jats:italic>.1\/6 patients), total bile acids (26(SE13)<jats:italic>v<\/jats:italic>.14(SE5)\u03bcmol\/l) or the ratio of tauro-conjugated:glyco-conjugated bile acids (5(SE2)<jats:italic>v<\/jats:italic>.8(SE 4)%, usual range 30\u201360%). After supplementation, there was an increase in plasma taurine level (63(SE8)<jats:italic>v<\/jats:italic>. 43(SE4),<jats:italic>P<\/jats:italic>=0\u00b7007) but was no change in either total bile acids or the ratio of tauro-conjugated: glyco-conjugated bile acids. There was a significant decrease in aspartate aminotransferase level. Long-term parenteral nutrition for short-bowel syndrome is associated with an impaired tauro-conjugation of bile acids (enterohepatic pool), irrespective of plasma taurine level (systemic pool) and despite long-term taurine intravenous supplementation.<\/jats:p>","DOI":"10.1079\/bjn20061826","type":"journal-article","created":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T12:19:37Z","timestamp":1154434777000},"page":"365-370","source":"Crossref","is-referenced-by-count":31,"title":["Taurine status and response to intravenous taurine supplementation in adults with short-bowel syndrome undergoing long-term parenteral nutrition: a pilot study"],"prefix":"10.1017","volume":"96","author":[{"given":"St\u00e9phane 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