{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T02:40:06Z","timestamp":1712889606429},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"unspecified","delay-in-days":8078,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Quantities of trace elements including copper, zinc, cobalt, manganese and iron were investigated in the liver tissue of rats at the acute or chronic stages of fascioliasis following treatment with zinc-copper hydroxochloride mixed crystals. Oral dosing (with food) of zinc\u2013copper mixed crystals to healthy rats increased zinc and copper levels in the liver and decreased the iron content compared with controls. Manganese and cobalt levels did not change significantly. Significant reductions in all trace elements except manganese occurred in the liver of rats with acute or chronic fascioliasis. Manganese levels were slightly increased in rats at the acute stage and slightly decreased in rats at the chronic stage of fascioliasis. The application of mixed zinc\u2013copper crystals at the acute or chronic stages of fascioliasis lead to a restoration of zinc and copper levels and a slight reduction in the iron levels in liver tissue of rats. The beneficial effects of applied salts were more apparent in rats chronically infected with <jats:italic>Fasciola hepatica<\/jats:italic>.<\/jats:p>","DOI":"10.1079\/joh200187","type":"journal-article","created":{"date-parts":[[2003,2,26]],"date-time":"2003-02-26T17:47:22Z","timestamp":1046281642000},"page":"87-89","source":"Crossref","is-referenced-by-count":0,"title":["Trace element levels in the liver of rats with acute and chronic fascioliasis and after treatment with zinc-copper hydroxochloride mixed crystals"],"prefix":"10.1017","volume":"76","author":[{"given":"N.T.","family":"Tsocheva-Gaitandjieva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.P.","family":"Gabrashanska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tepavitcharova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"S0022149X00701714_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00013286"},{"key":"S0022149X00701714_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0308-8146(92)90310-X"},{"key":"S0022149X00701714_ref015","first-page":"191","article-title":"Experimental studies with Stronglyloides papillosus in goats","volume":"66","author":"Pienaar","year":"1999","journal-title":"Onderstepoort Journal of Veterinary Research"},{"key":"S0022149X00701714_ref004","first-page":"181","volume-title":"Trace elements in medicine","author":"Fedosova","year":"1978"},{"key":"S0022149X00701714_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X99000050"},{"key":"S0022149X00701714_ref018","first-page":"115","article-title":"Trace element content of the rat liver after Fasciola hepatica infection and diethylnitrosamine intoxication","volume":"45","author":"Tsocheva","year":"1992","journal-title":"Comptes Rendus de l'Academie Bulgare des Sciences"},{"key":"S0022149X00701714_ref010","first-page":"199","article-title":"Comparison of the effects of basic and neutral zinc salts on chickens infected with Ascaridia galli","volume":"56","author":"Galvez-Morros","year":"1995","journal-title":"Parasitology Research"},{"key":"S0022149X00701714_ref021","first-page":"33","article-title":"Hidroxicloruro de zinc versus sulfato en la sobre carga oral de zinc","volume":"10","author":"Vazquez","year":"1990","journal-title":"Nutricion Clinica"},{"key":"S0022149X00701714_ref012","first-page":"124","article-title":"Prevalence of latent iron deficiency in patients with chronic S. mansoni infection","volume":"37","author":"Mansour","year":"1985","journal-title":"Tropical and Geographical Medicine"},{"key":"S0022149X00701714_ref014","first-page":"86","volume-title":"Biological role of trace elements in the constitution of animals and humans","author":"Nozdryuhina","year":"1977"},{"key":"S0022149X00701714_ref013","unstructured":"Markov, L. 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PhD thesis, Bulgarian Academy of Sciences, Sofia (in Bulgarian)."},{"key":"S0022149X00701714_ref022","first-page":"158","article-title":"Zinc serico y talla en una poblacion infantil de 5 a 15 anos.","author":"Vazquez","year":"1991","journal-title":"Nutricion Clinica"},{"key":"S0022149X00701714_ref011","doi-asserted-by":"publisher","DOI":"10.1007\/BF02917466"},{"key":"S0022149X00701714_ref020","first-page":"475","article-title":"Combined effect of fascioliasis and diethylnitrosamine carcinogenesis on the activity of the rat liver monooxygenase system","volume":"101C","author":"Tsocheva","year":"1992","journal-title":"Comparative Physiology and Biochemistry"},{"key":"S0022149X00701714_ref005","first-page":"97","article-title":"On the effect of copper salts (basic and neutral) during ascaridiosis on chicks","volume":"46","author":"Gabrashanska","year":"1993","journal-title":"Comptes Rendus de l'Academie Bulgare des Sciences"},{"key":"S0022149X00701714_ref001","first-page":"2","article-title":"On trace elements-like factors enhancing host-parasite relationships during helminthoses and in the possibility for their application for raising at animal production","volume":"30","author":"Davtyan","year":"1982","journal-title":"Biological Journal of Armenia"},{"key":"S0022149X00701714_ref008","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X99000517"},{"key":"S0022149X00701714_ref002","first-page":"3","article-title":"Mineral contents of helminths and their hosts. 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