{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:55:35Z","timestamp":1761486935850},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"unspecified","delay-in-days":8078,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of interferon (IFN) \u03b3 on the course of infection with <jats:italic>Strongyloides papillosus<\/jats:italic> in calves were investigated. Calves (N=7 each) were inoculated with recombinant bovine IFN\u03b3 or control solution daily from day 0 to day 15 following <jats:italic>S. papillosus<\/jats:italic> infection. Treatment with IFN\u03b3 induced an increase in faecal egg output in the peak stage of infection. The IFN\u03b3-treated animals harboured more worms, especially more immature worms, in the small intestine than control animals at necropsy on day 17, with no decreases in intestinal mucosal mast cells. Both animal groups had similar small numbers of intestinal worms at necropsy on day 26. All control animals developed peripheral blood eosinophilia on day 7, while five of seven IFN\u03b3-treated animals did not. Serum \u03b11-acid glycoprotein concentrations increased on day 7 in both animal groups, with higher values in control animals than in IFN\u03b3-treated animals. Control animals mounted a predominant IgG1 response to <jats:italic>S. papillosus<\/jats:italic> from day 10, while IFN\u03b3-treated animals did from day 22. These data suggested that IFN\u03b3 inhibited some host protective responses to <jats:italic>S. papillosus<\/jats:italic> migrating larvae, resulting in an improvement of worm survival after a period when protective responses should be activated during the early stage of infection. The effects of IFN\u03b3 on intestinal worm expulsion should be confirmed by further experiments.<\/jats:p>","DOI":"10.1079\/joh200196","type":"journal-article","created":{"date-parts":[[2003,2,26]],"date-time":"2003-02-26T17:47:22Z","timestamp":1046281642000},"page":"59-64","source":"Crossref","is-referenced-by-count":4,"title":["Effects of recombinant bovine interferon \u03b3 on <i>Strongyloides papillosus<\/i> infection in calves"],"prefix":"10.1017","volume":"76","author":[{"given":"Y.","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Syouji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Onodera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Inumaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yokomizo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"S0022149X00701672_ref018","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.56.1005"},{"key":"S0022149X00701672_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(93)90176-N"},{"key":"S0022149X00701672_ref016","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.12.4653-4660.1995"},{"key":"S0022149X00701672_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(93)90159-V"},{"key":"S0022149X00701672_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5288(93)90132-Y"},{"key":"S0022149X00701672_ref014","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1996.d01-92.x"},{"key":"S0022149X00701672_ref021","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00006647"},{"key":"S0022149X00701672_ref025","first-page":"536","article-title":"Experimental strongyloidiasis in sheep and goats. 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