{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:46:36Z","timestamp":1785321996410,"version":"3.55.0"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"unspecified","delay-in-days":7803,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of treatment with praziquantel (PZQ) on the tegument of adult <jats:italic>Schistosoma mansoni<\/jats:italic> worms and on liver egg-granulomas has been examined in mice infected with PZQ-resistant and -susceptible parasite isolates. Two PZQ-resistant <jats:italic>S. mansoni<\/jats:italic> isolates, one selected by passage in the laboratory under drug pressure and one from Senegal established from eggs excreted by an uncured patient, were compared with PZQ-susceptible control isolates. Scanning electron microscopic observations on the tegument of <jats:italic>Schistosoma<\/jats:italic> adult worms treated <jats:italic>in vivo<\/jats:italic> with PZQ showed that more severe damage was inflicted by PZQ on susceptible worms than on drug-resistant worms. Observations on the pathology of <jats:italic>Schistosoma<\/jats:italic> egg-granulomas in the liver of infected mice after treatment with PZQ indicated that eggs from susceptible control isolates were more sensitive to PZQ than those from drug-resistant isolates.<\/jats:p>","DOI":"10.1079\/joh2002135","type":"journal-article","created":{"date-parts":[[2003,2,26]],"date-time":"2003-02-26T17:47:22Z","timestamp":1046281642000},"page":"327-333","source":"Crossref","is-referenced-by-count":21,"title":["Adult worm tegumental damage and egg-granulomas in praziquantel-resistant and -susceptible Schistosoma mansoni treated in vivo"],"prefix":"10.1017","volume":"76","author":[{"given":"Y.-S.","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.C.","family":"Coles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-R.","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-C.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Doenhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"S0022149X00702069_ref023","first-page":"75","article-title":"Studies on granuloma formation III: antigen sequestration and destruction in the schistosome pseudotubercle","volume":"45","author":"Von Lichtenberg","year":"1964","journal-title":"American Journal of Pathology"},{"key":"S0022149X00702069_ref014","first-page":"544","article-title":"In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni, a light and electron microscopic study","volume":"31","author":"Mehlhorn","year":"1981","journal-title":"Arzneimittel-Forschung\/Drug Research"},{"key":"S0022149X00702069_ref026","unstructured":"World Health Organization (1993) The control of schistosomiasis. 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