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Vaccination studies with purified native and recombinant <jats:italic>Fasciola<\/jats:italic> antigens suggest that this approach to diminished morbidity and mortality and reduced transmission is a realistic goal. Among the major potential vaccine candidates are fatty acid binding protein (FABP), cysteine (cathepsin) proteases, haemoglobulin, leucine aminopeptidase, and a saposin-like protein. In the case of <jats:italic>Fasciola hepatica<\/jats:italic> FABP, cross-reaction and cross-protection against <jats:italic>Schistosoma mansoni<\/jats:italic> is an important feature. In addition to protective effects with significant worm burden reductions, some vaccine candidates also have anti-fecundity (smaller flukes), anti-pathology (less liver lesions), and anti-embryonation effects. Optimism is tempered by the fact that fascioliasis in humans is an orphan disease and in need of governmental and foundation support.<\/jats:p>","DOI":"10.1079\/joh2005304","type":"journal-article","created":{"date-parts":[[2005,9,12]],"date-time":"2005-09-12T22:05:11Z","timestamp":1126562711000},"page":"241-247","source":"Crossref","is-referenced-by-count":81,"title":["<i>Fasciola<\/i> antigens as vaccines against fascioliasis and 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