{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:33:34Z","timestamp":1777451614135,"version":"3.51.4"},"reference-count":149,"publisher":"Cambridge University Press (CUP)","issue":"2b","license":[{"start":{"date-parts":[[2007,9,27]],"date-time":"2007-09-27T00:00:00Z","timestamp":1190851200000},"content-version":"unspecified","delay-in-days":2370,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                    <jats:p>For decades it has been postulated that the main environmental factor\n                        for coronary heart disease (CHD) was the intake of saturated fatty acids\n                        (SFA). Nevertheless, confirmation of the role of SFA in CHD through\n                        intervention trials has been disappointing. It was only when the diet was\n                        enriched in n-3 fatty acids that CHD was significantly prevented, especially\n                        cardiac death.<\/jats:p>\n                    <jats:p>In addition to n-3 fatty acids, many other foodstuffs or nutrients such\n                        as fibers, antioxidants, folic acid, calcium and even alcohol contribute to\n                        prevent CHD. Thus the relationship between diet and CHD morbidity and\n                        mortality appears to be much more complex than formerly suspected\n                        considering as key factors only SFA, linoleic acid, cholesterol and\n                        atherosclerosis. Some of the mechanisms are briefly described, but many\n                        additional nutrients (or non nutrients) may also play an important role in\n                        the pathogenesis of CHD.<\/jats:p>\n                    <jats:p>Finally, as a result of the most recent epidemiologic studies the ideal\n                        diet may comprise: 8% energy from SFA, 5% from polyunsaturated fatty acids\n                        with a ratio 5\/1 of linoleic\/alpha-linolenic acid+longer chains n-3, oleic\n                        acid as desired, large intake of cereals, vegetables, legumes and fruits,\n                        fish twice a week, cheese and yogurt as dairy products, rapeseed and olive\n                        oils as edible fat. Without side effects, such a diet can be highly\n                        palatable, easily enjoyed by many populations and may prevent effectively\n                        and rapidly (within a few weeks or months) CHD.<\/jats:p>","DOI":"10.1079\/phn2001134","type":"journal-article","created":{"date-parts":[[2008,6,3]],"date-time":"2008-06-03T14:03:09Z","timestamp":1212501789000},"page":"459-474","source":"Crossref","is-referenced-by-count":40,"title":["Coronary heart disease: dietary links and pathogenesis"],"prefix":"10.1017","volume":"4","author":[{"given":"Serge","family":"Renaud","sequence":"first","affiliation":[{"name":"University Bordeaux 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Lanzmann-Petithory","sequence":"additional","affiliation":[{"name":"Henri Mondor Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,9,27]]},"reference":[{"key":"S1368980001001380_manual_ref-65","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.13.7.958"},{"key":"S1368980001001380_manual_ref-37","first-page":"62","volume-title":"The role of fats in Human Nutrition","author":"Crawford","year":"1985"},{"key":"S1368980001001380_manual_ref-86","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(93)90036-T"},{"key":"S1368980001001380_manual_ref-82","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199305203282004"},{"key":"S1368980001001380_manual_ref-141","first-page":"201","article-title":"Serum cholesteryl ester fatty acids and their relation with\n                            serum lipids in elderly men in Crete and the Netherlands","volume":"47","author":"Sandker","year":"1993","journal-title":"Eur. 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