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It is associated with increased susceptibility to infectious diseases in both man and animal models. Vitamin A also has a role as an anti-inflammatory agent. Supplementation with vitamin A has been found to be beneficial in a number of inflammatory conditions, including skin disorders such as acne vulgaris, broncho-pulmonary dysplasia and some forms of precancerous and cancer states. The present review suggests that vitamin A deficiency induces inflammation and aggravates existing inflammatory states. Supplementation with vitamin A in selected cases could ameliorate inflammation. The two main mechanisms which appear to be involved in the prevention of disease are the effects of vitamin A on the immune system and the effect on epithelial integrity.<\/jats:p>","DOI":"10.1079\/pns2002172","type":"journal-article","created":{"date-parts":[[2003,2,26]],"date-time":"2003-02-26T17:47:22Z","timestamp":1046281642000},"page":"397-400","source":"Crossref","is-referenced-by-count":110,"title":["Vitamin A as an anti-inflammatory agent"],"prefix":"10.1017","volume":"61","author":[{"given":"Ram","family":"Reifen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2008,7,28]]},"reference":[{"key":"S0029665102000393_ref029","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1017\/S0007114500070008","article-title":"Vitamin A deficiency induces morphometric changes and functionality in chicken small intestine","volume":"80","author":"Uni","year":"1998","journal-title":"British Journal 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