{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:13:31Z","timestamp":1771478011047,"version":"3.50.1"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T00:00:00Z","timestamp":1173052800000},"content-version":"unspecified","delay-in-days":1585,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proc. Nutr. Soc."],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>R\u00e9sum\u00e9<\/jats:p><jats:p>A la diff\u00e9rence des mutations g\u00e9n\u00e9tiques rares mais s\u00e9ve\u00e8res qui causent les maladies monog\u00e9niques, les facteurs g\u00e9n\u00e9tiques qui modulent la susceptibilit\u00e9 individuelle aux maladies multifactorielles (maladies cardiovasculaires, cancer, diabe\u00e8te) sont des formes fr\u00e9quentes, fonctionnellement diff\u00e9rentes, des ge`nes (polymorphismes) qui ont g\u00e9n\u00e9ralement un effet modeste au niveau individuel, mais en raison de leur grande fr\u00e9quence dans la population, peuvent \u00eatre associ\u00e9s \u00e0 un risque attribuable \u00e9lev\u00e9. Les facteurs environnementaux peuvent r\u00e9v\u00e9ler ou faciliter l'expression ph\u00e9notypique de ces ge`nes de susceptibilit\u00e9. En effet, dans le cas des maladies communes, les effets g\u00e9n\u00e9tiques peuvent etre consid\u00e9rablement amplifi\u00e9s en pr\u00e9sence de facteurs d\u00e9clenchants. On sait maintenant que la plupart des ge\u00e8nes de susceptibilit\u00e9 aux maladies communes n'ont pas un r\u00f4le \u00e9tiologique primaire dans la pr\u00e9disposition a` la maladie mais agissent plutot comme des modificateurs dans la r\u00e9ponse a` des facteurs exoge`nes tels que le stress, l'environnement, la maladie, la prise de m\u00e9dicament, le r\u00e9gime alimentaire. Une meilleure caract\u00e9risation des interactions entre facteurs g\u00e9n\u00e9tiques et environnementaux constitue un \u00e9l\u00e9ment cl\u00e9 dans la compr\u00e9hension de la pathog\u00e9ne\u00e8se des maladies multifactorielles. Cet article pr\u00e9sente trois exemples d'interaction g\u00e8ne-environnement dans le domaine des maladies coronariennes.<\/jats:p>","DOI":"10.1079\/pns2002178","type":"journal-article","created":{"date-parts":[[2003,3,5]],"date-time":"2003-03-05T01:25:06Z","timestamp":1046827506000},"page":"457-463","source":"Crossref","is-referenced-by-count":64,"title":["Gene-environment interaction: a central concept in multifactorial diseases"],"prefix":"10.1017","volume":"61","author":[{"given":"Laurence","family":"Tiret","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,5]]},"reference":[{"key":"S0029665102000472_ref006","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.3.733"},{"key":"S0029665102000472_ref007","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1056\/NEJM198911093211907","article-title":"HDL - the clinical implications of recent studies","volume":"321","author":"Gordon","year":"1989","journal-title":"New England Journal of Medicine"},{"key":"S0029665102000472_ref015","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0022-2275(20)36957-1","article-title":"Plasma cholesteryl ester transfer protein","volume":"34","author":"Tall","year":"1993","journal-title":"Journal of Lipid Research"},{"key":"S0029665102000472_ref004","first-page":"829","article-title":"Insulin stimulates endothelin-1 secretion from human endothelial cells and modulates its circulating levels in vivo","volume":"80","author":"Ferri","year":"1995","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"S0029665102000472_ref016","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.5.1169"},{"key":"S0029665102000472_ref012","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508103330607"},{"key":"S0029665102000472_ref014","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.5.1967"},{"key":"S0029665102000472_ref010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803193381202"},{"key":"S0029665102000472_ref001","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2272(200007)19:1<64::AID-GEPI5>3.0.CO;2-E"},{"key":"S0029665102000472_ref002","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.2.507"},{"key":"S0029665102000472_ref011","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801083380203"},{"key":"S0029665102000472_ref005","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118207"},{"key":"S0029665102000472_ref017","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.60.3.473"},{"key":"S0029665102000472_ref003","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/23.3.465"},{"key":"S0029665102000472_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)03033-X"},{"key":"S0029665102000472_ref008","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.4.526"},{"key":"S0029665102000472_ref009","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00548.x"}],"container-title":["Proceedings of the Nutrition Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0029665102000472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:53:06Z","timestamp":1622854386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0029665102000472\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["S0029665102000472"],"URL":"https:\/\/doi.org\/10.1079\/pns2002178","relation":{},"ISSN":["0029-6651","1475-2719"],"issn-type":[{"value":"0029-6651","type":"print"},{"value":"1475-2719","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}