{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:35:39Z","timestamp":1760708139266},"reference-count":84,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1735,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>C\u2010reactive protein is an acute phase protein widely used as an indicator of infectious or inflammatory conditions. Traditionally it has been used as an adjunctive test for inflammation and as a marker of disease activity. Though sensitive, its nonspecific nature imposes limitation on its clinical use. Currently C\u2010reactive protein is used in the management of chorioamnionitis, preterm premature rupture of membranes, pelvic inflammatory disease, and urinary tract infection. Interestingly, several obstetric conditions such as pre\u2010eclampsia and gestational diabetes are now known to have an underlying inflammatory basis and there is an emerging role of C\u2010reactive protein testing in managing these diseases. Additionally C\u2010reactive protein testing has an established place in management of several acute abdominal conditions. The aim of this paper is to review the place of C\u2010reactive protein in modern obstetric and gynecological practice.<\/jats:p>","DOI":"10.1080\/00016340500432614","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T17:35:29Z","timestamp":1260293729000},"page":"394-401","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The role of C\u2010reactive protein in modern obstetric and gynecological practice"],"prefix":"10.1111","volume":"85","author":[{"given":"MOHAMMAD M.","family":"AZIZIA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAURIE M.","family":"IRVINE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARCELLINA","family":"COKER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FATAI A.","family":"SANUSI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.52.4.561"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.73.2.173"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.73.2.183"},{"key":"e_1_2_8_5_2","first-page":"313","article-title":"C\u2010reactive protein and the acute phase response","volume":"37","author":"Ballou SP","year":"1992","journal-title":"Adv Intern Med"},{"issue":"11","key":"e_1_2_8_6_2","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1093\/clinchem\/43.11.2017","article-title":"C\u2010reactive protein \u2013 undervalued, underutilized","volume":"43","author":"Gambino R","year":"1997","journal-title":"Clin Chem"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb23995.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80193-2"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91565-8"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1986.tb02746.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199708000-00003"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.41.11.1203"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.56.2.126"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.2.115"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.1860040316"},{"issue":"5","key":"e_1_2_8_16_2","first-page":"313","article-title":"Evaluation of an improved immunoturbidimetic assay for serum C\u2010reactive protein on a COBAS INTEGRA 400 Analyzer","volume":"48","author":"Sanchez A","year":"2002","journal-title":"Clin Lab"},{"key":"e_1_2_8_17_2","first-page":"1075","article-title":"Evaluation of the nephelometric assay of CRP using the Beckman ICS","volume":"27","author":"Van Lente F","year":"1981","journal-title":"Clin Chem"},{"key":"e_1_2_8_18_2","first-page":"324","article-title":"The acute phase response and laboratory testing","volume":"25","author":"Jupe D","year":"1996","journal-title":"Aust Fam Phys"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365518009095582"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00084-8"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313029109060809"},{"issue":"6","key":"e_1_2_8_22_2","first-page":"671","article-title":"Premature rupture of the membranes","volume":"60","author":"Gibbs RS","year":"1982","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02390652"},{"issue":"8","key":"e_1_2_8_24_2","first-page":"615","article-title":"Intrauterine infections. I. The role of C\u2010reactive protein, white blood cell count and erythrocyte sedimentation rate in pregnant women in the detection of intrauterine infection after preliminary rupture of membranes]","volume":"69","author":"Nowak M","year":"1998","journal-title":"Ginekol Pol"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(80)90082-4"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90285-6"},{"issue":"2","key":"e_1_2_8_27_2","first-page":"31","article-title":"Predictive value of C\u2010reactive protein in serum of maternal and cord blood in cases with premature rupture of membranes","volume":"9","author":"Awara AM","year":"1992","journal-title":"Egypt Med J"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1987.tb02316.x"},{"issue":"3","key":"e_1_2_8_29_2","first-page":"515","article-title":"C\u2010reactive proteins as an indicator of sub\u2010clinical infection in cases of premature rupture of membranes","volume":"46","author":"Saini S","year":"2003","journal-title":"Indian J Pathol Microbiol"},{"issue":"1","key":"e_1_2_8_30_2","first-page":"S360","article-title":"The role of maternal serum C\u2010reactive protein and white blood cell count in the prediction of chorioamnionitis in women with premature rupture of membranes","volume":"84","author":"Sereepapong W","year":"2001","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)90437-X"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(83)91104-3"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-0412.2003.00223.x"},{"issue":"21","key":"e_1_2_8_34_2","first-page":"1411","article-title":"C\u2010reactive protein in the maternal serum and risk of fetal infection in premature rupture of the fetal membranes and threatened premature labor]","volume":"111","author":"Hirsch W","year":"1989","journal-title":"Zentralbl Gynakol"},{"issue":"11","key":"e_1_2_8_35_2","first-page":"690","article-title":"C\u2010reactive protein as a predictor of fetal and maternal infective morbidity and fetal mortality","volume":"71","author":"de Souza JJ","year":"1987","journal-title":"S Afr Med J"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6042.965"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.12968\/hosp.2003.64.11.2343"},{"issue":"20","key":"e_1_2_8_38_2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1471-0528.2003.00025.x","article-title":"The role of infection in preterm labour","volume":"110","author":"Friese K","year":"2003","journal-title":"BJOG"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00564.x"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.339"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1989.tb02391.x"},{"issue":"10","key":"e_1_2_8_42_2","first-page":"799","article-title":"Relationship between C\u2010reactive protein levels and intraamniotic infection in women with preterm labor","volume":"38","author":"Mazor M","year":"1993","journal-title":"J Reprod Med"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199310000-00007"},{"issue":"3","key":"e_1_2_8_44_2","first-page":"132","article-title":"C\u2010reactive protein as a marker of infection in women with preterm delivery]","volume":"124","author":"Mazor M","year":"1993","journal-title":"Harefuah"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(85)80249-0"},{"issue":"10","key":"e_1_2_8_46_2","first-page":"555","article-title":"Puerperium after threatened premature labor \u2013 positive effects of infection screening by determination of CRP in pregnancy]","volume":"116","author":"Winkler M","year":"1994","journal-title":"Zentralbl Gynakol"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2002.810509.x"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.119628"},{"key":"e_1_2_8_49_2","doi-asserted-by":"crossref","unstructured":"Kenyon S Boulvain M Neilson J.Antibiotics for preterm rupture of membranes.Cochrane Database Syst Rev2003 2:CD001058.","DOI":"10.1002\/14651858.CD001058"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(99)00297-3"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)91474-B"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90271-J"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90419-9"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(97)00236-1"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(90)90478-4"},{"issue":"10","key":"e_1_2_8_56_2","first-page":"955","article-title":"C\u2010reactive protein in assessing antimicrobial treatment of acute pelvic inflammatory disease","volume":"35","author":"Teisala K","year":"1990","journal-title":"J Reprod Med"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1975.tb03822.x"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80229-1"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365548909035682"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.10.2569"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.3.693"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.3.819"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2004.00578.x"},{"issue":"3","key":"e_1_2_8_64_2","first-page":"21","article-title":"Hormone therapy and the cardiovascular system: the critical role of progestins","volume":"6","author":"Sitruk\u2010Ware RL","year":"2003","journal-title":"Climacteric"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2004.02.004"},{"issue":"21","key":"e_1_2_8_66_2","first-page":"II2","article-title":"Inflammation as a cardiovascular risk factor","volume":"109","author":"Willerson JT","year":"2004","journal-title":"Circulation"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.122414"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802713"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70254-6"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70239-5"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh179"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2003.09.011"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(02)00085-2"},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01551-4"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(01)00499-4"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.1081\/PRG-120021059"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365519709084584"},{"key":"e_1_2_8_78_2","doi-asserted-by":"publisher","DOI":"10.1024\/1023-9332.6.4.169"},{"key":"e_1_2_8_79_2","first-page":"365","article-title":"Diagnostic accuracy of ultrasonography and C\u2010reactive protein concentration in acute cholecystitis: a prospective clinical study","volume":"158","author":"Juvonen T","year":"1992","journal-title":"Eur J Surg"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.4065\/71.12.1138"},{"key":"e_1_2_8_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(92)90030-M"},{"key":"e_1_2_8_82_2","doi-asserted-by":"publisher","DOI":"10.1179\/027249304225018948"},{"key":"e_1_2_8_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050715"},{"key":"e_1_2_8_84_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.022095"},{"key":"e_1_2_8_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(95)00485-8"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F00016340500432614","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/00016340500432614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:31:13Z","timestamp":1697430673000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1080\/00016340500432614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":84,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1080\/00016340500432614"],"URL":"https:\/\/doi.org\/10.1080\/00016340500432614","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"2010-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}