{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:45:59Z","timestamp":1791308759997,"version":"4.3.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1582,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background.<\/jats:italic> Chronic hypertension during pregnancy is associated with an increased risk for birth of small for gestational age offspring. The aim of this study was to determine whether the risk remains after consideration of maternal characteristics and superimposed pre\u2010eclampsia. <jats:italic>Method.<\/jats:italic> A population\u2010based cohort study based on the Swedish Medical Birth Register 1992\u201398 and comprising 560 188 women aged 15\u201344 years with singleton pregnancies including 2,754 women with chronic hypertension. The register contains data of maternal characteristics besides maternal and fetal complications. Multiple logistic regression analysis was used. Small for gestational age was defined as birth weight less than \u22122SD adjusted for gestational age and sex. <jats:italic>Results.<\/jats:italic> Chronic hypertensive women have an independent risk for small for gestational age (OR 3.1; 95% CI 2.7\u20133.7) when controlling for confounding of maternal characteristics such as age, parity, BMI, smoking, and ethnical origin. After introducing superimposed pre\u2010eclampsia in the model the risk remains but decreases (OR 2.4; 95% CI 2.1\u20132.9). <jats:italic>Conclusion.<\/jats:italic> Chronic hypertension is an independent risk factor for birth of small for gestational age offspring. Pre\u2010eclampsia is a strong mediating factor.<\/jats:p>","DOI":"10.1080\/00016340500442654","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T17:34:28Z","timestamp":1260293668000},"page":"1046-1050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Chronic hypertension as a risk factor for offspring to be born small for gestational age"],"prefix":"10.1111","volume":"85","author":[{"given":"Karin","family":"Zetterstr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solveig","family":"Nord\u00e9n Lindeberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Haglund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(76)90671-2"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-198602000-00008"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90276-3"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199405000-00015"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199507000-00011"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09662.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/145.8.689"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00387-7"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801153380302"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)01040-1"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(01)00181-5"},{"issue":"5","key":"e_1_2_7_13_2","first-page":"571","article-title":"Pregnancy outcome in 211 patients with mild chronic hypertension","volume":"61","author":"Sibai BM","year":"1983","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90387-M"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809033391004"},{"issue":"6","key":"e_1_2_7_16_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1742-1241.2001.tb11064.x","article-title":"The prevalence of pre\u2010eclampsia and obstetric outcome in pregnancies of normotensive and hypertensive women attending a hospital specialist clinic","volume":"55","author":"Lydakis C","year":"2001","journal-title":"Int J Clin Pract"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/140349489001800209"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90090-7"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2002.0105"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1081\/PRG-120013785"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-4-17"},{"issue":"4","key":"e_1_2_7_23_2","first-page":"517","article-title":"Pregnancy outcome of intensive therapy in severe hypertension in first trimester","volume":"67","author":"Sibai BM","year":"1986","journal-title":"Obstet Gynecol"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F00016340500442654","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/00016340500442654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T13:51:00Z","timestamp":1697032260000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1080\/00016340500442654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1080\/00016340500442654"],"URL":"https:\/\/doi.org\/10.1080\/00016340500442654","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]},"assertion":[{"value":"2010-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}