{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:03:14Z","timestamp":1759564994450},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1582,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background.<\/jats:italic> To study the rate of regression and progression into invasive disease of patients with histologically proven carcinoma <jats:italic>in situ<\/jats:italic> of the uterine cervix during pregnancy. <jats:italic>Methods<\/jats:italic>. Prospective observation of all pregnant women with biopsy\u2010proven carcinoma <jats:italic>in situ<\/jats:italic> of the uterine cervix, gained by colposcopic guided biopsy from 1996 to 2004 and correlation with the route of delivery and cytologic and histologic postpartum findings. <jats:italic>Results.<\/jats:italic> Eighty\u2010three patients with histologically verified carcinoma <jats:italic>in situ<\/jats:italic> during pregnancy were treated conservatively. Two patients were lost to follow\u2010up, one patient had an abortion, and three are still pregnant. The study population of 77 patients were followed for a median of 140 days before delivery. Postpartum regression rate was 34.2%, two patients had a diagnosis of microinvasive cervical cancer on the postpartum cone biopsy, and persistent carcinoma <jats:italic>in situ<\/jats:italic> was found postpartum in 63.1% of patients. No difference was seen for the route of delivery. Both patients with microinvasive carcinoma were delivered by primary cesarean section and are disease\u2010free after 24 and 38 months, respectively. <jats:italic>Conclusions.<\/jats:italic> We recommend conservative management for women with carcinoma <jats:italic>in situ<\/jats:italic> of the uterine cervix. We found no difference for the route of delivery regarding postpartum regression and recommend a postpartum evaluation after the puerperium. Colposcopic guided biopsy should rule out an invasive process during pregnancy. Cesarean section as the mode of delivery should be considered, if invasion is suspected.<\/jats:p>","DOI":"10.1080\/00016340600555926","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T17:34:28Z","timestamp":1260293668000},"page":"1134-1137","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Management and course of histologically verified cervical carcinoma <i>in situ<\/i> during pregnancy"],"prefix":"10.1111","volume":"85","author":[{"given":"S.","family":"Ackermann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gehrsitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Mehlhorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.W.","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0889-8545(21)00292-8","article-title":"Colposcopy in pregnancy","volume":"20","author":"Campion MJ","year":"1993","journal-title":"Obstet Gynecol Clin North Am"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199310000-00024"},{"key":"e_1_2_6_4_2","first-page":"735","article-title":"Carcinoma of the cervix associated with pregnancy","volume":"59","author":"Hacker NF","year":"1982","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_5_2","first-page":"583","article-title":"Carcinoma of the uterine cervix in pregnancy. 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