{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:47:01Z","timestamp":1773974821813,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1674,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Aim.<\/jats:italic> To study the risk for complications during pregnancy, delivery, and neonatal period after the use of antiepileptic drugs (AEDs) during pregnancy.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> Women treated with AEDs during pregnancy and with singleton deliveries were identified from the Swedish Medical Birth Registry during the period July 1 1995 to and including 2001 <jats:italic>(n<\/jats:italic> = 1350). Risk estimates were made using the Mantel\u2010Haenszel procedure and comparisons with all singleton births in Sweden during this period <jats:italic>(n<\/jats:italic> = 559 491). Stratification was made for year of birth, maternal age, parity, and smoking habits.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Most of the women <jats:italic>(n<\/jats:italic> = 1207, 89%) used AEDs in monotherapy. Carbamazepine was the most commonly used drug <jats:italic>(n<\/jats:italic> = 683), followed by valproic acid <jats:italic>(n<\/jats:italic> = 255). The rate of caesarean sections was significantly increased (OR = 1.64, 95% CI 1.43\u20131.89), but it was not possible to differentiate between elective and emergency sections. The risk for pre\u2010eclampsia (OR = 1.66, 95% CI 1.32\u20132.08) and for hemorrhage after vaginal delivery was increased (OR = 1.29, 95% CI 1.02\u20131.63). The neonates showed an increased risk for respiratory distress (OR = 2.06, 95% CI 1.62\u20132.63).<\/jats:p><jats:p><jats:italic>Conclusion.<\/jats:italic> The study demonstrates a slightly increased risk only for preeclampsia, vaginal hemorrhage after delivery, and respiratory distress in the newborn after the use of AEDs during pregnancy.<\/jats:p>","DOI":"10.1080\/00016340600604625","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T17:34:49Z","timestamp":1260293689000},"page":"643-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Pregnancy, delivery, and neonatal complications after treatment with antiepileptic drugs"],"prefix":"10.1111","volume":"85","author":[{"given":"Christina","family":"Pilo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Wide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birger","family":"Winbladh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"212","article-title":"Epilepsy and pregnancy","volume":"11","author":"Crawford P","year":"2002","journal-title":"Seizure"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1998.tb00631.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000052902"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01186.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/seiz.1998.0239"},{"key":"e_1_2_7_7_2","first-page":"60","article-title":"Pregnancy in women with epilepsy: preliminary results of Kerala Registry of Epilepsy and Pregnancy","volume":"49","author":"Thomas SV","year":"2001","journal-title":"Neurol India"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00253.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/140349489001800209"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/seiz.2001.0562"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30567-0"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199243060-00006"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F00016340600604625","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/00016340600604625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T12:27:11Z","timestamp":1697372831000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1080\/00016340600604625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1080\/00016340600604625"],"URL":"https:\/\/doi.org\/10.1080\/00016340600604625","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"2010-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}