{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:49:57Z","timestamp":1787503797944,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1613,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Background.<\/jats:italic>\n                    Under most circumstances with altered growth hormone (GH) secretion, the changes of insulin\u2010like growth factor I (IGF\u2010I), insulin\u2010like growth factor binding protein 3 (IGFBP\u20103), and acid\u2010labile subunit (ALS) are in parallel. The aim of the present study was to compare the effects of pregnancy in a hypopituitary patient with those of pregnancy in an acromegalic patient on IGF\u2010I, IGFBP\u20103, and ALS.\n                    <jats:italic>Methods and results.<\/jats:italic>\n                    IGF\u2010I and ALS were low before pregnancy in the hypopituitary patient under glucocorticoid and thyroxine treatment. Gonadotropin treatment allowed her to become pregnant; IGF\u2010I and ALS levels rose in the second half of pregnancy and fell again after delivery. IGF\u2010I concentrations were elevated in the patient with persistent acromegaly before and dropped into the normal range during the first half of pregnancy. In the second half of pregnancy and following delivery, IGF\u2010I levels increased again. IGFBP\u20103 levels (as assessed by immunoblot analysis as well as by\n                    <jats:sup>125<\/jats:sup>\n                    I\u2010IGF II ligand blotting) decreased markedly during pregnancy in both patients, suggesting that the placenta rather than pituitary GH regulates IGFBP\u20103 proteolysis in human pregnancy. The increase of IGF\u2010I (and ALS) during the second half of pregnancy in the individual with pituitary GH deficiency may be attributed to placental GH. The fall of IGF\u2010I (and ALS) into the normal range in the acromegalic patient during the first trimester of pregnancy may be related to decreased production or decreased half\u2010life of these proteins.\n                    <jats:italic>Conclusion.<\/jats:italic>\n                    Our data suggest that measures to continuously replace GH or to suppress GH secretion during pregnancy in patients with GH deficiency or excess, respectively, may not be warranted.\n                  <\/jats:p>","DOI":"10.1080\/00016340600676532","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T12:34:45Z","timestamp":1260275685000},"page":"900-905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Pregnancy\u2010induced changes in insulin\u2010like growth factor I (IGF\u2010I), insulin\u2010like growth factor binding protein 3 (IGFBP\u20103), and acid\u2010labile subunit (ALS) in patients with 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