{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:54:14Z","timestamp":1791975254780,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1491,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2006,12]]},"abstract":"Abstract<\/jats:title>Objective.<\/jats:italic> To present cycle characteristics and results of in vitro<\/jats:italic> fertilization in 27 patients with hypogonadotropic hypogonadism. Further, to demonstrate the consequences of advanced age (\u226535 years). Methods.<\/jats:italic> Data from 27 hypogonadotropic hypogonadism patients treated with in vitro<\/jats:italic> fertilization in the period from 2000 to 2004 were analyzed and compared with treatment results from 39 patients with unexplained infertility. Moreover, data from hypogonadotropic hypogonadism patients were analyzed according to the age factor. Mann\u2013Whitney U, Chi\u2010square, and Student's t<\/jats:italic>\u2010tests were used for statistical analysis. p<\/jats:italic><0.05 was considered significant. Results.<\/jats:italic> Higher gonadotropin consumption and a longer stimulation period were observed in the hypogonadotropic hypogonadism group. Peak E2 levels, and the total number of oocytes and metaphase II oocytes were higher in the unexplained infertility group. Although a higher number of grade I embryos were transferred in the unexplained infertility group, the implantation rate was found to be better in the hypogonadotropic hypogonadism group (36.5% versus 13%; p<\/jats:italic><0.0001). Pregnancy rates were similar. When hypogonadotropic hypogonadism patients were evaluated according to the age factor, no significant difference was found with regard to cycle and outcome parameters, except higher gonadotropin consumption in aged patients. In aged hypogonadotropic hypogonadism patients, a pregnancy rate of 50% was achieved. Conclusion.<\/jats:italic> Hypogonadotropic hypogonadism women undergoing in vitro<\/jats:italic> fertilization were found to be good responders. In the presence of advanced age, management of these patients becomes challenging. However, even these patients still have a good chance of pregnancy.<\/jats:p>","DOI":"10.1080\/00016340600839619","type":"journal-article","created":{"date-parts":[[2009,12,8]],"date-time":"2009-12-08T17:34:16Z","timestamp":1260293656000},"page":"1453-1457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Women with hypogonadotropic hypogonadism: cycle characteristics and results of assisted reproductive techniques"],"prefix":"10.1111","volume":"85","author":[{"given":"BANU","family":"KUMBAK","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEMRA","family":"KAHRAMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.12.2525"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/gye.16.1.27.32"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55852-X"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136154"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1742-1241.2002.tb11215.x","article-title":"Successful pregnancy following gonadotropin therapy in a patient with hypogonadotropic hypogonadism resulting from craniopharyngioma","volume":"56","author":"Hayashi M","year":"2002","journal-title":"Int J Clin Pract"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.3.726"},{"key":"e_1_2_5_8_2","volume-title":"Atlas of Human Gametes and Conceptuses","author":"Veeck LL","year":"1999"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54911-5"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00599-9"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-005-4914-6"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01555203"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01133247"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F00016340600839619","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/00016340600839619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T06:59:31Z","timestamp":1697439571000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1080\/00016340600839619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1080\/00016340600839619"],"URL":"https:\/\/doi.org\/10.1080\/00016340600839619","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]},"assertion":[{"value":"2010-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}