{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:54:31Z","timestamp":1770508471070,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1429,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>. Open fetal neural tube defects are often followed by an increase in alpha\u2010Fetoprotein concentration in amniotic fluid. For over 25 years there has been a routine to measure amniotic fluid alpha\u2010Fetoprotein in conjunction with early genetic amniocentesis. The efficacy of such a screening test in a low\u2010risk population has been questioned but never evaluated in a Swedish population. <jats:italic>Methods.<\/jats:italic> Data were reviewed retrospectively from all consecutive early second\u2010trimester genetic amniocenteses from two hospitals during the years 1993\u20132003. Indications for the genetic amniocenteses were maternal age \u226535 years, maternal anxiety or a history of fetal aneuploidy. A questionnaire was sent to all obstetric clinics in Sweden regarding current common policy and experience of routine amniotic fluid alpha\u2010Fetoprotein measurements, in the detection of open fetal neural tube defects. <jats:italic>Results.<\/jats:italic> A total of 1,813 samples were included. In eight cases (0.4%) the amniotic fluid alpha\u2010Fetoprotein concentrations were \u22653 multiples of median, but five of them were false positive (63%). Out of the three true positive cases, one had clinical relevance. In the other two cases the detection of open fetal neural tube defects was of subordinate importance. In Sweden, during 2004, 91% of the obstetric clinics performed routine assessment of amniotic fluid alpha\u2010Fetoprotein at second\u2010trimester genetic amniocentesis, but only 9% regarded the analysis useful in clinical practice. <jats:italic>Conclusions.<\/jats:italic> According to our results, routine measurement of amniotic fluid alpha\u2010Fetoprotein in early second\u2010trimester genetic amniocentesis, to rule out a risk of open fetal neural tube defects, does not seem justified. The clinical usefulness seems to be limited.<\/jats:p>","DOI":"10.1080\/00016340601048012","type":"journal-article","created":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T02:27:53Z","timestamp":1175221673000},"page":"167-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Routine assessment of amniotic fluid alpha\u2010Fetoprotein in early second\u2010trimester amniocentesis is no longer justified"],"prefix":"10.1111","volume":"86","author":[{"given":"KJERSTIN","family":"FERM WIDLUND","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOMAS","family":"GOTTVALL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)91634-0"},{"key":"e_1_2_7_3_2","first-page":"651","article-title":"Amniotic fluid alpha\u2010fetoprotein measurement in antenatal diagnosis of anencephaly and open spina bifida in early pregnancy","author":"United Kingdom Collaborative Study on Alpha\u2010fetoprotein in Relation to Neural Tube Defect","year":"1979","journal-title":"Lancet"},{"key":"e_1_2_7_4_2","first-page":"126","article-title":"Interpreting elevated amniotic fluid alpha\u2010fetoprotein levels in clinical practice: use of predictive value positive concept","volume":"133","author":"Goldberg MF","year":"1979","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_7_5_2","first-page":"532","article-title":"Prenatal diagnosis of neural tube defects. 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