{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:40:32Z","timestamp":1790127632866,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1370,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background.<\/jats:italic> The unquestionable benefit of antiretroviral therapy in reducing the rate of mother\u2010to\u2010child transmission can be lessened by potential maternal or neonatal toxicity. <jats:italic>Objective.<\/jats:italic> To analyze obstetric and perinatal complications in a cohort of HIV\u2010infected pregnant women and their relationship with maternal antiretroviral therapy. <jats:italic>Population.<\/jats:italic> One hundred and sixty\u2010seven HIV\u2010infected pregnant women who delivered at Hospital Universitario La Paz, Madrid, Spain between January 1997 and December 2003. <jats:italic>Methods.<\/jats:italic> Data on the clinical and epidemiological characteristics of HIV\u2010infected patients, previous and current antiretroviral therapy, gestational diabetes mellitus, length of pregnancy, mode of delivery, and weight of the newborn were collected. Pregnancy outcomes were compared with those of all the pregnant women attended at our hospital. <jats:italic>Main outcome measures.<\/jats:italic> Gestational diabetes mellitus, premature delivery, and low birth weight. <jats:italic>Results.<\/jats:italic> Gestational diabetes mellitus was diagnosed in 8.9% of patients. All the cases of gestational diabetes were in the combined antiretroviral therapy group, and the majority were receiving triple antiretroviral therapy with a protease inhibitor. The risk of developing this pathology was greater among women receiving antiretroviral therapy prior to pregnancy. The premature delivery rate was 29% and the low birth weight rate was 28%. <jats:italic>Conclusion.<\/jats:italic> Gestational diabetes mellitus is more common in HIV\u2010infected women than in the general population and is related to combined antiretroviral therapy, especially the use of protease inhibitors, which suggests the need for close follow\u2010up during pregnancy in HIV\u2010infected patients. Nevertheless, the adverse perinatal consequences observed were more related to maternal factors than to antiretroviral therapy.<\/jats:p>","DOI":"10.1080\/00016340601148531","type":"journal-article","created":{"date-parts":[[2007,5,24]],"date-time":"2007-05-24T17:51:00Z","timestamp":1180029060000},"page":"409-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Obstetric and perinatal complications in HIV\u2010infected women. Analysis of a cohort of 167 pregnancies between 1997 and 2003"],"prefix":"10.1111","volume":"86","author":[{"given":"COVADONGA","family":"MART\u00cd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOSE M.","family":"PE\u00d1A","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ISABEL","family":"BATES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROSARIO","family":"MADERO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ISABEL","family":"DE JOS\u00c9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LUIS FELIPE","family":"PALLARDO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOSE","family":"RAM\u00d3N ARRIBAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUAN","family":"GONZALEZ\u2010GARCIA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANTONIO","family":"GONZALEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUAN","family":"JOS\u00c9 VAZQUEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411033311801"},{"issue":"5","key":"e_1_2_5_3_2","first-page":"1","article-title":"Report of the NIH to define principles of the therapy of HIV infection","volume":"47","author":"CDC","year":"1998","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70519-2"},{"issue":"2","key":"e_1_2_5_5_2","first-page":"1","article-title":"US Public Health Service Task Force. Recommendations for the use of antiretroviral drugs in pregnant women infected with HIV\u20101 for maternal health and for reducing perinatal HIV\u20101 transmission in the United States","volume":"47","author":"CDC","year":"1998","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0213-005X(01)72652-3"},{"key":"e_1_2_5_7_2","unstructured":"CDC. US Public Health Service Task Force. Recommendations for use of antiretroviral drugs in pregnant HIV\u20101 women infected for maternal health and Interventions to reduce perinatal HIV\u20101 transmission in the United States. November 17 2005. 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[Screening for gestational diabetes with the one hour 50 g glucose test: prevalence and relationship with risk factors] (in Spanish with English abstract)","volume":"93","author":"Diez JJ","year":"1989","journal-title":"Med Clin (Barc)"},{"key":"e_1_2_5_13_2","first-page":"435","article-title":"Pregnancy in HIV\u2010positive women: 6 years of activity of the Regional Reference Center","volume":"57","author":"Bernardom M","year":"2005","journal-title":"Minerva Ginecol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2005.00755.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1157\/13090377"},{"key":"e_1_2_5_16_2","unstructured":"Sociedad Espa\u00f1ola Ginecolog\u00eda y Obstetricia. Base de datos perinatales2002. (in Spanish). Available on WWW at:http:\/\/www.sego.es."},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210748"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000139398.38236.4d"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/00126334-200012010-00003","article-title":"Multicenter review of protease inhibitors in 89 pregnancies","volume":"25","author":"Morris AB","year":"2000","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000207657.94360.78"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.07.018"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000168973.59466.14"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.576"},{"key":"e_1_2_5_24_2","unstructured":"Public Health Service Task Force. 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