{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:03:43Z","timestamp":1762160623513},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1370,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background.<\/jats:italic> Peritoneal adhesion is a common complication following abdominal surgery. Despite recent advances in diagnosis and treatment, it still presents a problem for the patients and surgeons. In the present study, we investigated the effects of octenidindihydro\u2010chloride \u2013 phenoxyethanol (OCP) on peritoneal adhesions. <jats:italic>Method.<\/jats:italic> Rats were divided into four groups: Group 1 (saline), Group 2 (peritonitis plus saline), Group 3 (OCP), and Group 4 (peritonitis plus OCP). Peritonitis was induced in the rats of Groups 2 and 4. The abdominal cavities of the rats in Groups 1 and 2 were washed with saline, while those of the rats in Groups 3 and 4 were irrigated with 1:10 OCP solution. Adhesion and fibrotic scores were determined by re\u2010laparotomy after 21 days. <jats:italic>Results.<\/jats:italic> The adhesion scores in Groups 1 (saline), 2 (peritonitis plus saline), 3 (OCP) and 4 (peritonitis plus OCP) were 3.30\u00b10.94, 5.25\u00b11.03, 1.12\u00b10.83 and 0.28\u00b10.48, respectively. Statistical analysis of adhesion scores revealed significant differences between groups, except between Groups 3 and 4 (<jats:italic>p<\/jats:italic> = 0.265). Statistical analyses of grades of histopathological signs showed that Group 1 differed from Groups 2 and 4 (<jats:italic>p<\/jats:italic> = 0.004, <jats:italic>p<\/jats:italic> = 0.003, respectively); Group 2 differed from Groups 3 and 4 (<jats:italic>p<\/jats:italic> = 0.001, <jats:italic>p<\/jats:italic> = 0.001, respectively). On the other hand, differences between Group 3 and Groups 1 and 4 were not significant (<jats:italic>p<\/jats:italic> = 0.06, <jats:italic>p<\/jats:italic> = 0.08, respectively). <jats:italic>Conclusion.<\/jats:italic> OCP decreased the peritoneal adhesion formation macroscopically and microscopically in the presence or absence of peritonitis. Peritoneal defects due to trauma are to be left open and OCP diluted 1:1 should not be used intraperitoneally.<\/jats:p>","DOI":"10.1080\/00016340701267108","type":"journal-article","created":{"date-parts":[[2007,5,24]],"date-time":"2007-05-24T17:50:43Z","timestamp":1180029043000},"page":"395-400","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intraperitoneal octenidindihydro\u2010chloride \u2013 phenoxyethanol solution to prevent peritoneal adhesion formation in a rat peritonitis 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