{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:59:05Z","timestamp":1782514745302,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1248,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background.<\/jats:italic> Evidence of vulvar human papillomavirus infection varies and the frequency of the different genotypes has not been adequately assessed. <jats:italic>Methods.<\/jats:italic> Fifty consecutive sexually active healthy patients with vulvodynia and suspected of human papillomavirus infection underwent a vulvoscopy and biopsy. Ten normal vulvar samples were also enrolled as control. Histological and vulvoscopic findings were compared in relation to human papillomavirus\u2010DNA presence and genotyping by a broad\u2010spectrum polymerase chain reaction and reverse hybridization line probe assay. <jats:italic>Results.<\/jats:italic> Although the clinical and histological diagnoses did not always coincide, a good association was found (<jats:italic>p<\/jats:italic>&lt;0.0001). Human papillomavirus\u2010DNA was detected in 42% of all biopsies and in none of the controls, and less frequently in acetowhite\u2010positive patients (33.3%, <jats:italic>p<\/jats:italic>&lt;0.03). Squamous papillomatosis (74%) was the most frequent histological diagnosis, followed by condyloma (20%). Condyloma (90%) but not squamous papillomatosis (29.7%) was significantly associated with human papillomavirus\u2010DNA presence. Out of the vulvoscopically normal patients, one (33%) was human papillomavirus\u2010DNA positive. Out of the recorded microscopic features, only koilocytosis was associated with human papillomavirus\u2010DNA presence. Eight different human papillomavirus genotypes were detected: high\u2010risk 16 (43%), 31 (19%), 52 (14.3%), 68, and 59 (4.8% each), and low\u2010risk types 6 (71.4%), 11, and 40 (4.8% each); 33.3% of infections were multiple, ranging from 2 to 4 genotypes. Out of the human papillomavirus\u2010DNA positive squamous papillomatosis, 72.7% showed a high\u2010risk type but the infection remained episomal. <jats:italic>Conclusions.<\/jats:italic> Our data confirm human papillomavirus as a frequent cause of vulvodynia and its frequent association with squamous papillomatosis or condyloma. The high\u2010risk human papillomavirus in squamous papillomatosis suggests screening for possible undiagnosed cervical infection.<\/jats:p>","DOI":"10.1080\/00016340701417455","type":"journal-article","created":{"date-parts":[[2007,7,25]],"date-time":"2007-07-25T03:45:50Z","timestamp":1185335150000},"page":"1003-1010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence and genotyping of human papillomavirus infection in women with vulvodynia"],"prefix":"10.1111","volume":"86","author":[{"given":"AUGUSTO","family":"ORLANDI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARIANNA","family":"FRANCESCONI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CATERINA","family":"ANGELONI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GIAMPIERO","family":"PALMIERI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GLORIA","family":"FULVIA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARCO","family":"CIOTTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANNA","family":"CRISCUOLO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRANCESCO","family":"SESTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LUIGI GIUSTO","family":"SPAGNOLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910520513"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950615)75:12<2879::AID-CNCR2820751214>3.0.CO;2-W"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc798"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.10.003"},{"key":"e_1_2_7_8_2","first-page":"376","article-title":"Condylomata acuminata \u2013 past and present","volume":"47","author":"Bafverstedt B","year":"1967","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016348809004188"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31801997000200003"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890350103"},{"key":"e_1_2_7_12_2","first-page":"966","article-title":"Deceptive vulvar papillomavirus infection. 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