{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T07:39:53Z","timestamp":1794037193801,"version":"4.8.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1217,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objectives.<\/jats:italic> To investigate whether tranexamic acid (Transamin\u00ae) therapy reduces the amount of menstrual blood loss (MBL) and occurrence of menorrhagia after intrauterine device (IUD) insertion. <jats:italic>Methods.<\/jats:italic> Some 175 Chinese women attending for IUD insertion were equally assigned into 2 Transamin\u00ae groups (1,000 and 500 mg, twice daily) and a placebo group. Their MBL was recorded with a pictorial chart in 3 subsequent menstrual cycles after insertion, while the MBL of 64 patients, collecting used sanitary towels, was also measured by an alkaline hematin method. <jats:italic>Results.<\/jats:italic> A significant decline in post\u2010insertion MBL and occurrence of menorrhagia was found in the 2 Transamin\u00ae groups compared with the placebo group (<jats:italic>p<\/jats:italic>&lt;0.05), whereas the difference in the results from the pictorial chart score was not statistically significant between the 1 g group and placebo group. <jats:italic>Conclusion.<\/jats:italic> Transamin\u00ae treatment with a generally recommended dosage can effectively reduce the amount of IUD\u2010induced MBL and prevent menorrhagia in Chinese women. A lower dosage than recommended (50% of recommended dosage) may have a similar preventive effect.<\/jats:p>","DOI":"10.1080\/00016340701516777","type":"journal-article","created":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T12:16:31Z","timestamp":1187784991000},"page":"1126-1129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Preventive treatment of intrauterine device\u2010induced menstrual blood loss with tranexamic acid in Chinese women"],"prefix":"10.1111","volume":"86","author":[{"given":"X.","family":"LIN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.S.","family":"GAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.X.","family":"DOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"YUAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/101053959801000107"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(98)00126-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(99)00077-3"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(96)00181-3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(02)00385-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(03)00111-2"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(99)00027-X"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1879-3479.1979.tb00474.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(83)90084-7"},{"issue":"3","key":"e_1_2_6_11_2","first-page":"59","article-title":"Changes of peroxidase, plasminogen and fibrinolytic activity on menorrhagia induced by IUDS and the effect of treatment with vitamin E","volume":"7","author":"Zhang PC","year":"1987","journal-title":"Shengzhi Yu Biyun"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","unstructured":"Lethaby A Farquhar C Cooke I.Antifibrinolytics for heavy menstrual bleeding.Cochrane Database Syst Rev2000; 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