{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T19:30:08Z","timestamp":1787427008611,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1187,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background.<\/jats:italic> The main purpose of this study is to review the clinical features of negative loop electrosurgical procedure (LEEP)\u2010cones, in order to lower their rate. <jats:italic>Methods.<\/jats:italic> Some 162 patients with LEEP\u2010cones were reviewed. Control cytology, satisfactory\u2010unsatisfactory colposcopy, biopsies and endocervical curettage (ECC) were compared to the presence or absence of cone pathology. Statistical analysis, <jats:italic>t<\/jats:italic>\u2010tests and Pearson \u03c7<jats:sup>2<\/jats:sup> tests were performed, with a significance level of <jats:italic>p<\/jats:italic>&lt;0.05. <jats:italic>Results.<\/jats:italic> Negative cones are associated with unsatisfactory colposcopy in 47\/60 cases (78.3%) compared to 13\/60 (21.8%) for satisfactory colposcopy (<jats:italic>p<\/jats:italic> = 0.011). Unsatisfactory colposcopy is associated with a negative ECC in 53\/74 (71.6%) cases, compared to 21\/74 (28.4%) for satisfactory colposcopy (<jats:italic>p<\/jats:italic> = 0.024). Finally, negative ECC are associated with negative cones in 32\/41 (78%) compared to 9\/41 (22%) for positive ECC (<jats:italic>p<\/jats:italic> = 0.002). <jats:italic>Conclusions.<\/jats:italic> Low grade cytology, CIN1 biopsies and ECC should be followed for at least 1 year. This results in a lowering of cone negativity from 60\/162 (37%) to 32\/162 (19.8%).<\/jats:p>","DOI":"10.1080\/00016340701552475","type":"journal-article","created":{"date-parts":[[2007,9,23]],"date-time":"2007-09-23T02:18:34Z","timestamp":1190513914000},"page":"1269-1272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Correlations between unsatisfactory colposcopy, cytology, and biopsy in patients with cervical abnormalities"],"prefix":"10.1111","volume":"86","author":[{"given":"B.","family":"LAMBERT","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"LEPAGE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2599"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000172427.44160.0e"},{"issue":"3","key":"e_1_2_8_4_2","first-page":"645","article-title":"Abnormal cervical cytology and histology","volume":"106","author":"ACOG Practice Bulletin","year":"2005","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_5_2","first-page":"1054","article-title":"Large loop excision of the transformation zone (LLETZ): a new method of management for women with cervical intraepithelial neoplasia","volume":"96","author":"Prendiville W","year":"1989","journal-title":"Obstet Gynecol"},{"issue":"4","key":"e_1_2_8_6_2","first-page":"23S","article-title":"Negative cervical cones and clinicopathologic predictors","volume":"105","author":"Wagreich AR","year":"2005","journal-title":"Obstet Gynecol"},{"issue":"8","key":"e_1_2_8_7_2","first-page":"617","article-title":"Negative cone biopsies a reappraisal","volume":"48","author":"Diakomanolis E","year":"2003","journal-title":"J Reprod Med"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00128360-199807000-00001"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(91)90007-R"},{"key":"e_1_2_8_10_2","first-page":"1020","article-title":"Loop electrosurgical excision procedure of the transformation zone and colposcopically directed punch biopsy in the diagnosis of cervical lesions","volume":"80","author":"Bonardi R","year":"1992","journal-title":"Obstet Gynecol"},{"issue":"6","key":"e_1_2_8_11_2","first-page":"905","article-title":"The histological reliability of laser cone biopsy of the cervix","volume":"77","author":"Howell R","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11103.x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00128360-200204000-00004"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000230258.07737.fa"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/518439"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000192169.44775.76"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.lgt.0000210129.93392.2c"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F00016340701552475","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/00016340701552475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:33:22Z","timestamp":1697416402000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1080\/00016340701552475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1080\/00016340701552475"],"URL":"https:\/\/doi.org\/10.1080\/00016340701552475","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10]]},"assertion":[{"value":"2010-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}