{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:53:11Z","timestamp":1776786791958,"version":"3.51.2"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1095,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To evaluate the efficacy of prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) for cervical ripening at preterm and to identify factors predicting ripening failure. <jats:italic>Design.<\/jats:italic> A retrospective study of women admitted for preinduction cervical ripening with PGE<jats:sub>2<\/jats:sub> vaginal tablets at preterm (<jats:italic>n<\/jats:italic> = 444). PGE<jats:sub>2<\/jats:sub> vaginal tablets were administered at 6\u20138 h intervals until cervical ripening was achieved (Bishop score \u22657) or ripening failed (Bishop score &lt;7 after administration of 4 PGE<jats:sub>2<\/jats:sub> tablets). Data were compared with a control group of women admitted for preinduction cervical ripening with PGE<jats:sub>2<\/jats:sub> vaginal tablets at term (<jats:italic>n<\/jats:italic> = 1,029). A multivariate logistic regression analysis was performed to detect factors predicting ripening failure. <jats:italic>Results.<\/jats:italic> Women at preterm required a significantly higher number of PGE<jats:sub>2<\/jats:sub> tablets compared to women at term (2.0\u00b11.1 versus 1.6\u00b10.9, <jats:italic>p<\/jats:italic>&lt;0.001). Overall rates of ripening failure and caesarean section due to failed induction were significantly higher in preterm than term gestations (11.4 versus 1.1% and 9.7 versus 0.4%, <jats:italic>p<\/jats:italic> &lt;0.001), and were inversely related to gestational age. Nulliparity, lower gestational age at delivery, lack of cervical dilatation, and higher maternal age were significant predictors of ripening failure at preterm. <jats:italic>Conclusion.<\/jats:italic> The use of PGE<jats:sub>2<\/jats:sub> for preinduction cervical ripening at preterm may be associated with an increased risk of ripening failure and caesarean section compared with term gestations. This information may be useful when consulting women regarding the available options when premature delivery is necessary.<\/jats:p>","DOI":"10.1080\/00016340701778773","type":"journal-article","created":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T21:39:18Z","timestamp":1198273158000},"page":"63-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Preinduction cervical ripening with prostaglandin E<sub>2<\/sub> at preterm"],"prefix":"10.1111","volume":"87","author":[{"given":"NIR","family":"MELAMED","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YARIV","family":"YOGEV","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ERAN","family":"HADAR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MOSHE","family":"HOD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AVI","family":"BEN\u2010HAROUSH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","unstructured":"Kelly AJ Kavanagh J Thomas J.Vaginal prostaglandin (PGE2and PGF2a) for induction of labour at term.Cochrane Database Syst Rev2003;4:CD003101.","DOI":"10.1002\/14651858.CD003101"},{"key":"e_1_2_5_3_2","unstructured":"RCOG.Induction of labour Evidence\u2010based Clinical Guidelines No. 9;2001."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.14.1.30.34"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(90)90583-7"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(96)00086-X"},{"issue":"5","key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/jmf.10.5.305.311","article-title":"Labor induction for the preterm severe pre\u2010eclamptic patient: is it worth the effort?","volume":"10","author":"Blackwell SC","year":"2001","journal-title":"J Matern Fetal Med"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(02)00101-X"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90712-X"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90278-Y"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/6.4.375"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200609000-00015"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1977.tb12574.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00764-6"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(95)00146-4"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200009000-00003"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999360"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2004.00321.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(00)00103-9"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-3278(03)00113-3"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00115-X"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F00016340701778773","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/00016340701778773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T11:34:32Z","timestamp":1697024072000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1080\/00016340701778773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1080\/00016340701778773"],"URL":"https:\/\/doi.org\/10.1080\/00016340701778773","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"2010-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}