{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:16:39Z","timestamp":1767842199679,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1064,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objectives.<\/jats:italic> To clarify the change of peripheral CD<jats:sub>4<\/jats:sub><jats:sup>+<\/jats:sup>CD<jats:sub>25<\/jats:sub><jats:sup>+<\/jats:sup> regulatory T lymphocytes in normal pregnancy and pre\u2010eclampsia and to explore its role in the pathogenesis of pre\u2010eclampsia. <jats:italic>Methods.<\/jats:italic> Twenty\u2010seven women with pre\u2010eclampsia, 27 with normal third trimester pregnancy and 27 healthy non\u2010pregnant women were recruited. Blood samples were taken and surface antigen CD<jats:sub>4<\/jats:sub> and CD<jats:sub>25<\/jats:sub> were labelled with fluorescence\u2010conjugated antibodies. CD<jats:sub>4<\/jats:sub><jats:sup>+<\/jats:sup>CD<jats:sub>25<\/jats:sub><jats:sup>+<\/jats:sup> regulatory T cells were analysed by flow cytometry, and the proportion in T cells and the amount of regulatory T lymphocytes were calculated. <jats:italic>Results.<\/jats:italic> The amount and the proportion of regulatory T cells were not significantly different among non\u2010pregnant, normal pregnancy and pre\u2010eclampsia groups (<jats:italic>p<\/jats:italic>&gt;0.05 for both). There were no significant differences in the proportion and the amount of CD<jats:sub>4<\/jats:sub><jats:sup>+<\/jats:sup>CD<jats:sub>25<\/jats:sub><jats:sup>+<\/jats:sup> regulatory T cells between mild and severe pre\u2010eclampsia subgroups (<jats:italic>p<\/jats:italic>&gt;0.05 for both). <jats:italic>Conclusions.<\/jats:italic> No significant change of peripheral regulatory T cells was observed in the current investigation, suggesting other mechanisms rather than CD<jats:sub>4<\/jats:sub><jats:sup>+<\/jats:sup>CD<jats:sub>25<\/jats:sub><jats:sup>+<\/jats:sup> regulatory T cells were involved in the pathogenesis of pre\u2010eclampsia.<\/jats:p>","DOI":"10.1080\/00016340701823991","type":"journal-article","created":{"date-parts":[[2008,1,29]],"date-time":"2008-01-29T12:56:49Z","timestamp":1201611409000},"page":"190-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Alteration of peripheral CD<sub>4<\/sub><sup>+<\/sup>CD<sub>25<\/sub><sup>+<\/sup> regulatory T lymphocytes in pregnancy and pre\u2010eclampsia"],"prefix":"10.1111","volume":"87","author":[{"given":"DONGXIAO","family":"HU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YAN","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WUWEN","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HANZHI","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZHENGPING","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MINYUE","family":"DONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000188408.49896.c5"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3280d942e9"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2007.02.006"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000087912"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1037"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.9.2736"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1178"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah044"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01747-1"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535428"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01869.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03397.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.11.008"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00334.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2007.00489.x"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F00016340701823991","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/00016340701823991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:17:03Z","timestamp":1697429823000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1080\/00016340701823991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1080\/00016340701823991"],"URL":"https:\/\/doi.org\/10.1080\/00016340701823991","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"2010-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}