{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:01:31Z","timestamp":1779310891738,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":1004,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To investigate the frequency of the interleukin\u201010 (IL\u201010)\u22121082 G\/A single nucleotide polymorphism in women with intrauterine fetal death (IUFD), pre\u2010eclampsia (PE), preterm delivery (PD), and small for gestational age (SGA) infants. <jats:italic>Methods.<\/jats:italic> In a prospective cohort study, DNA from 1,616 consecutive pregnant women was analyzed for IL\u201010 \u22121082 G\/A by polymerase chain reaction. Women who developed at least one of the predefined pregnancy complications were used as cases and compared to women without pregnancy complications. <jats:italic>Results.<\/jats:italic> Of 1,616 women, 254 (15.7%) developed at least one pregnancy complication. IL\u201010 \u22121082 G\/A allele frequencies (G: 233\/508 [45.9%] and A: 275\/508 [54.1%] versus G: 1,143\/2,724 [42.0%] and A: 1,581\/2,724 [58.0%], respectively; <jats:italic>p<\/jats:italic> = 0.10; OR 0.85; 95% CI 0.69\u20131.04) and genotype distributions (A\/A+G\/A: 201\/254 [79.1%] and G\/G 53\/254 [20.9%] versus A\/A+G\/A: 1,125\/1,362 [82.6%] and G\/G 237\/1,362 [17.4%], respectively, <jats:italic>p<\/jats:italic> = 0.19; OR 0.79; 95% CI 0.54\u20131.15) were not significantly different between cases and controls. We observed no statistically significant difference in IL\u201010 \u22121082 G\/A genotype distribution comparing controls and women with IUFD, PE, PD &lt;37 weeks gestation, and SGA infants (&lt;10th percentile). <jats:italic>Conclusion.<\/jats:italic> IL\u201010 \u22121082 G\/A polymorphism is not a genetic marker for identifying women at increased risk of common pregnancy complications.<\/jats:p>","DOI":"10.1080\/00016340801995657","type":"journal-article","created":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T18:05:45Z","timestamp":1207073145000},"page":"430-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Interleukin\u201010 \u22121082 G\/A promoter polymorphism and pregnancy complications: results of a prospective cohort study in 1,616 pregnant women"],"prefix":"10.1111","volume":"87","author":[{"given":"FELIX","family":"STONEK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTIN","family":"METZENBAUER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ERICH","family":"HAFNER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KARL","family":"PHILIPP","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CLEMENS","family":"TEMPFER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1517\/phgs.5.1.57.25687"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.701"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00711.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91358-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2370.1997.tb00001.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2006.00386.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.05.003"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00341.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.09.066"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01747-1"},{"key":"e_1_2_5_12_2","first-page":"167","article-title":"Intrauterine Wachstumskurven f\u00fcr den deutschsprachigen Raum","volume":"184","author":"Hohenauer L","year":"1980","journal-title":"Zentralblatt Geb Perinatol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.2001.5565"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.08.291"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F00016340801995657","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/00016340801995657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T08:35:18Z","timestamp":1695803718000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1080\/00016340801995657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1080\/00016340801995657"],"URL":"https:\/\/doi.org\/10.1080\/00016340801995657","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"2010-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}