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Although they are benign tumors that are often asymptomatic, uterine fibroids may cause debilitating symptoms in many women, such as abnormal uterine bleeding, abdominal pain, increased abdominal girth, urinary frequency, constipation, pregnancy loss, dyspareunia, and in some cases infertility. Several approaches are available for the treatment of uterine fibroids. These include pharmacologic options, such as hormonal therapies and gonadotropin\u2010releasing hormone agonists; surgical approaches, such as hysterectomy, myomectomy, myolysis, laparoscopic uterine artery occlusion, magnetic resonance imaging\u2010guided focused ultrasound surgery, and uterine artery embolization. The choice of approach may be dictated by factors such as the patient's desire to become pregnant in the future, the importance of uterine preservation, symptom severity, and tumor characteristics. New treatment options for uterine fibroids would be minimally invasive, have long\u2010term data demonstrating efficacy and safety, have minimal or no incidence of fibroid recurrence, be easy to perform, preserve fertility, and be cost effective. New treatment approaches are under investigation, with the goals of being effective, safe, and less invasive.<\/jats:p>","DOI":"10.1080\/00016340802146912","type":"journal-article","created":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T14:02:07Z","timestamp":1213970527000},"page":"812-823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Modern management of uterine fibroids"],"prefix":"10.1111","volume":"87","author":[{"given":"BARBARA S.","family":"LEVY","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2005.05.022"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200106000-00024"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.99"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2005.05.023"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000076690"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00418-0"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1377"},{"key":"e_1_2_9_9_2","first-page":"251","article-title":"Relationship between obesity and uterine leiomyomata","volume":"7","author":"Shikora SA","year":"1991","journal-title":"Nutrition"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.EDE.0000054360.61254.27"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000136079.62513.39"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm013"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cult.2007.08.011"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e31805f6cf2"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61708-4"},{"key":"e_1_2_9_16_2","first-page":"414","article-title":"Uterine sarcoma in patients operated on for presumed leiomyoma and rapidly growing leiomyoma","volume":"83","author":"Parker WH","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02511-5"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000243776.23391.7b"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del035"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2379"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0898"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.094"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem026"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)62236-5"},{"key":"e_1_2_9_25_2","unstructured":"Georgia Reproductive Specialists.Leiomyomas of the uterus\u2010fibroid tumors. 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