{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:17:15Z","timestamp":1790201835329,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":790,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The recommended dosage of tinzaparin in the treatment of thromboembolism during pregnancy is 175 IU\/kg\/day, as for non\u2010pregnant subjects. In clinical practice, we have experienced a need for a higher dosage, especially in the initial phase of the treatment of deep vein thrombosis, based on four\u2010hour post\u2010dose measurements of anti\u2010Xa activity.<\/jats:p><jats:p>Twenty\u2010two pregnant patients with a confirmed deep venous thrombosis were treated with tinzaparin either in a once\u2010 or twice\u2010daily regimen. Four\u2010hour post\u2010dosage plasma anti\u2010Xa activity was measured in 357 sequential blood samples during treatment. An higher dosage than recommended, was required to maintain anti\u2010Xa activity in the target range. We suggest that the starting dosage should be 250 IU\/kg\/day in a twice\u2010daily regimen, and that the dose in the initial phase be adjusted by daily monitoring of anti\u2010Xa.<\/jats:p>","DOI":"10.1080\/00016340802449118","type":"journal-article","created":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T15:44:13Z","timestamp":1223653453000},"page":"1248-1251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Treatment of deep venous thrombosis in pregnant women"],"prefix":"10.1111","volume":"87","author":[{"given":"JACOB A.","family":"LYKKE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THOR","family":"GR\u00d8NLYKKE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JENS","family":"LANGHOFF\u2010ROOS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06826.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0626"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1_suppl.64S"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1160\/TH06-10-0606","article-title":"The management of thrombosis in pregnancy: role of low\u2010molecular\u2010weight heparin","volume":"97","author":"Kher A","year":"2007","journal-title":"Thromb Haemost"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1160\/TH03-10-0618","article-title":"Low molecular weight heparin (tinzaparin) therapy for moderate risk thromboprophylaxis during pregnancy. A pharmacokinetic study","volume":"92","author":"Norris LA","year":"2004","journal-title":"Thromb Haemost"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05304.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.3_suppl.627S"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464130-00006"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02182.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043452811"},{"key":"e_1_2_6_12_2","volume-title":"Thromboembolic disease in pregnancy and the puerperium: acute management, (RCOG Green\u2010Top Guideline No. 28)","author":"Greer I","year":"2007"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1055\/s-0037-1613442","article-title":"Risk factors and coagulation parameters in relationship to phlebographic response and clinical outcome in the treatment of acute deep vein thrombosis","volume":"89","author":"Breddin HK","year":"2003","journal-title":"Thromb Haemost"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199903000-00011"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F00016340802449118","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/00016340802449118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:24:35Z","timestamp":1696983875000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1080\/00016340802449118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1080\/00016340802449118"],"URL":"https:\/\/doi.org\/10.1080\/00016340802449118","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"2010-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}