{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:07:15Z","timestamp":1780085235168,"version":"3.54.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":760,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. It is uncertain whether pregnancy influences the natural history of cervical intraepithelial neoplasia (CIN). Our aim was to evaluate the evolution of CIN in pregnant women. <jats:italic>Design<\/jats:italic>. Prospective study. <jats:italic>Setting<\/jats:italic>. Department of Obstetrics and Gynaecology, University of Insubria, Italy. <jats:italic>Population<\/jats:italic>. Women with histological CIN during pregnancy. <jats:italic>Methods and main outcome measures<\/jats:italic>. Between 2003 and 2007, women with an abnormal Pap\u2010smear during pregnancy underwent colposcopy. Patients with histological CIN were followed during pregnancy with colposcopy every 8 weeks and post\u2010partum evaluation was scheduled 3\u20136 months after delivery. Women with post\u2010partum histological diagnosis of CIN 2\u20133 underwent conization. To understand the impact of pregnancy on the evolution of CIN, women with CIN 1 discovered during pregnancy were compared to a group of non\u2010pregnant fertile patients with first diagnosis of CIN 1. <jats:italic>Results<\/jats:italic>. A total of 78 women were included: 36 (46.2%) with CIN 2\u20133 and 42 (53.8%) with CIN 1. In women with CIN 2\u20133, no invasion was suspected during pregnancy and at post\u2010partum evaluation, no invasive or microinvasive cancer, and 19 (52.7%) persistent CIN 2\u20133, and 17 (47.3%) regressions were diagnosed. In the group of CIN 1, we recorded six (14.3%) progressions to CIN 2\u20133, seven (16.6%) persistent CIN 1 and 29 (69%) regressions. The control group of non\u2010pregnant women had a lower regression rate (37\/76: 48.7%) in comparison to pregnant women (<jats:italic>p<\/jats:italic> = 0.03). <jats:italic>Conclusions<\/jats:italic>. Expectant management for CIN 2\u20133 diagnosed during gestation is safe. When discovered during pregnancy, CIN 1 has a significantly higher tendency to spontaneous regression in comparison to non\u2010pregnant condition.<\/jats:p>","DOI":"10.1080\/00016340802482986","type":"journal-article","created":{"date-parts":[[2008,10,24]],"date-time":"2008-10-24T12:02:20Z","timestamp":1224849740000},"page":"1296-1300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Natural history of cervical intraepithelial neoplasia during pregnancy"],"prefix":"10.1111","volume":"87","author":[{"given":"MAURIZIO","family":"SERATI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEFANO","family":"UCCELLA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROSA 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