{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:21:34Z","timestamp":1793366494275,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":698,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To investigate the efficacy of conization followed by conservative management for treating stage IA1 microinvasive carcinoma of the uterine cervix. <jats:italic>Design\/Setting.<\/jats:italic> Retrospective study. <jats:italic>Population.<\/jats:italic> Seventy\u2010five patients treated for stage IA1 microinvasive carcinoma of the cervix. Patients underwent conization followed by hysterectomy (Group 1, 53 patients), or were followed by conservative management (Group 2, 22 patients). <jats:italic>Methods.<\/jats:italic> Medical and histopathological record review. <jats:italic>Results.<\/jats:italic> For Group 1, pathology results showed that 30 had no residual tumor, one had cervical intraepithelial neoplasia (CIN) I, 11 had CIN III\/cervical carcinoma in situ (CIS), nine had microinvasive carcinomas, and one had an invasive carcinoma (outcome for one patient not recorded). For Group 2, secondary procedures involved only cervical smears for 12 (48%) patients, of whom nine had normal cytology, one had low\u2010grade squamous intraepithelial lesion and two had high\u2010grade squamous intraepithelial lesions. For 13 (52%) patients in Group 2, secondary procedures involved repeat conization on whom six had no residual tumor, one had CIN II, four CIN III\/CIS, and two microinvasive carcinoma and a negative resection margin. Therefore, conization followed by conservative management was an effective treatment for 90.9% (20\/22) of Group 2. In neither group was recurrence recorded. There was no relation between lymphovascular invasion and follow\u2010up cytology or pathology results, or between resection margin status and follow\u2010up examination results. <jats:italic>Conclusion.<\/jats:italic> Conization alone with careful follow\u2010up appears to be an effective and safe treatment for patients with stage IA1 microinvasive carcinoma of the uterine cervix, regardless of resection margins status or lymphovascular invasion.<\/jats:p>","DOI":"10.1080\/00016340802596009","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T16:48:52Z","timestamp":1229532532000},"page":"209-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["The efficacy of conservative management after conization in patients with stage IA1 microinvasive cervical carcinoma"],"prefix":"10.1111","volume":"88","author":[{"given":"SHIN WHA","family":"LEE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YONG\u2010MAN","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WOO\u2010SEOK","family":"SON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HANG\u2010JO","family":"YOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAE\u2010YEON","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JONG\u2010HYEOK","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOUNG\u2010TAK","family":"KIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOO\u2010HYUN","family":"NAM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"198","article-title":"Die Fr\u00fchdiagnose des Kollumkarzinoms","volume":"69","author":"Mestwerdt G","year":"1947","journal-title":"Z Geburtshilfe Gynakol."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.1203"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.07.062"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200001000-00005"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01683-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5825"},{"key":"e_1_2_6_8_2","first-page":"352","article-title":"Combination laser conization as treatment of microinvasive carcinoma of the uterine cervix","volume":"19","author":"Andersen ES","year":"1998","journal-title":"Eur J Gynaecol Oncol."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70394-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00414-6"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1997.4665"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.0277"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2003.00124.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90105-X"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(89)90070-X"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90899-I"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(89)90510-6"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910215)67:4<1037::AID-CNCR2820670429>3.0.CO;2-2"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921015)70:8<2121::AID-CNCR2820700819>3.0.CO;2-S"},{"key":"e_1_2_6_20_2","first-page":"465","article-title":"Microinvasive carcinoma of the cervix. 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