{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:03:28Z","timestamp":1791813808165,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":698,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> To evaluate the prognostic significance of the interaction between umbilical artery (UA) and middle cerebral artery (MCA) Doppler measurements in pregnancies complicated by fetal growth restriction (FGR). <jats:italic>Design.<\/jats:italic> Cohort study. <jats:italic>Setting.<\/jats:italic> Third\u2010level Perinatology Center in Northern Italy. <jats:italic>Population.<\/jats:italic> A study of 184 singleton pregnancies at 24\u201335 weeks\u2019 gestational age complicated by FGR and abnormal UA Doppler measurements. <jats:italic>Methods.<\/jats:italic> FGR was diagnosed by serial ultrasonograms. Neonatal brain damage was defined as the presence of cystic leukomalacia or grade III\u2010IV intraventricular hemorrhage. <jats:italic>Main outcome measures.<\/jats:italic> Perinatal death and neonatal brain damage. <jats:italic>Results.<\/jats:italic> The prevalence of fetal\/neonatal death or brain damage was 18.2% (16\/88) in pregnancies with UA absent\/reversed diastolic flow and 4.2% (4\/96) in those with increased UA Doppler pulsatility. Stepwise logistic regression identified decreasing gestational age (OR = 1.75, 95% confidence interval, CI = 1.35\u20132.22) and absent\/reversed UA blood flow (OR = 3.34, 95% CI = 1.1\u201310.9) as predictors of fetal\/neonatal death or brain damage. A MCA pulsatility index below the 10th percentile was a risk factor for fetal\/neonatal death or brain damage among women with absent\/reversed UA diastolic flow (14\/53 as compared to 2\/35; OR = 5.9, CI =1.4\u201340.3) but not in pregnancies with forward velocity (1\/33 as compared to 3\/63; OR = 0.63, 95% CI = 0.02\u20136.13, Synergy index = 27.7, <jats:italic>p<\/jats:italic> = 0.007). <jats:italic>Conclusions.<\/jats:italic> In pregnancies complicated by FGR and absent\/reversed UA end diastolic flow, vasodilatation of the MCA is a risk factor for neonatal death or brain damage.<\/jats:p>","DOI":"10.1080\/00016340802632358","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T16:15:24Z","timestamp":1232727324000},"page":"159-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Prognostic significance of the interaction between abnormal umbilical and middle cerebral artery Doppler velocimetry in pregnancies complicated by fetal growth restriction"],"prefix":"10.1111","volume":"88","author":[{"given":"ARSENIO","family":"SPINILLO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LAURA","family":"MONTANARI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIANNA","family":"ROCCIO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SILVIA","family":"ZANCHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRYSSOULA","family":"TZIALLA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAURO","family":"STRONATI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13075.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01780-X"},{"key":"e_1_2_6_4_2","unstructured":"Royal College of Obstetricians and Gynaecologists.The investigation and management of the small for gestational age fetus. 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