{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:03Z","timestamp":1778284803098,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":698,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To evaluate the pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate (CC). <jats:italic>Design<\/jats:italic>. A prospective, randomized, controlled trial. <jats:italic>Setting<\/jats:italic>. A university hospital center and a private practice setting. <jats:italic>Population<\/jats:italic>. The study comprised a total of 796 infertile women (1,100 cycles) and 200 spontaneously pregnant women (298 cycles) as a control group. <jats:italic>Methods<\/jats:italic>. Patients were allocated treatment either with 100 mg of CC daily (420 patients, 634 cycles), 5 mg of letrozole daily (269 patients, 323 cycles) or 1 mg of anastrozole daily (107 patients, 143 cycles) for 5 days starting on day 3 of menses. <jats:italic>Main outcome measures<\/jats:italic>. The occurrence of pregnancy, miscarriage and neonatal condition. <jats:italic>Results<\/jats:italic>. Pregnancy occurred in 167\/1,398 cycles (11.9%) in total without significant differences between groups. The total miscarriage rate was 16.1% (varied between 14.2% in CC group and 19.9% in anastrozole group) without difference between spontaneous and stimulated pregnancies. There were 129 deliveries in all groups. There were no significant differences between the stimulated and spontaneous pregnancies as regards mean gestational age, premature deliveries, birth weight, SGA&lt;10th percentile or five minutes Apgar score. There was one case of complete cleft palate and one case of major congenital heart problem in the letrozole group. There were two cases of talipus equinovarus in the CC and spontaneous pregnancy group. <jats:italic>Conclusion<\/jats:italic>. Aromatase inhibitors and CC resulted in favorable pregnancy outcomes and average miscarriage rates. Safety of the drugs for both the mother and fetuses was documented.<\/jats:p>","DOI":"10.1080\/00016340802638199","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T16:48:53Z","timestamp":1229532533000},"page":"187-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate in unexplained infertility"],"prefix":"10.1111","volume":"88","author":[{"given":"AHMED","family":"BADAWY","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAREK","family":"SHOKEIR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ABDEL FATTAH","family":"ALLAM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HESHAM","family":"ABDELHADY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01705-2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.09.045"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.04.070"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)03280-0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.03.001"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.02.070"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.07.230"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137165"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54772-4"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55855-5"},{"key":"e_1_2_6_12_2","unstructured":"BadawyA AbdelAli I Abu ElattaM.Clomiphene citrate or letrozole for ovulation induction in women with polycystic ovarian syndrome? A prospective randomized trial.Fertility & Sterility Online.19 June 2007(2007.02.062)."},{"key":"e_1_2_6_13_2","unstructured":"BadawyA Abdel AllIAbu ElattaM.Clomiphene citrate or anastrozole for ovulation induction in women with polycystic ovarian syndrome? A prospective controlled trial.Fertil Steril.2007(In Press)."},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016348809004181"},{"key":"e_1_2_6_15_2","first-page":"790","article-title":"Complications of pregnancy in infertile couples: routine treatment versus assisted reproduction","volume":"75","author":"Hill GA","year":"1990","journal-title":"Obstet Gynecol."},{"key":"e_1_2_6_16_2","unstructured":"FontanaPG LeclercJM.Contraindication of Femara\u00ae (letrozole) in premenopausal women.http:\/\/www.ca.novartis.com\/downloads\/en\/letters\/femara\u2010hcp\u2010e\u201017\u20101105.pdf."},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(03)00358-3"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.08.013"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.03.014"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199909)60:3<143::AID-TERA9>3.0.CO;2-#"},{"key":"e_1_2_6_21_2","first-page":"662","volume-title":"55th ed. 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