{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:42:27Z","timestamp":1782391347031,"version":"3.54.5"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":698,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To show that early discontinuation of oxytocin will not increase the mean duration of the active labor phase in a clinically significant way. <jats:italic>Design<\/jats:italic>. Controlled non\u2010inferiority study. <jats:italic>Setting<\/jats:italic>. Department of Obstetrics and Gynecology, University of Caen, Cl\u00e9menceau Hospital, France. <jats:italic>Population<\/jats:italic>. A total of 138 women with singleton pregnancy and a vertex presentation of over 34 gestational weeks, presenting a medical indication of induction of labor or a dystocia at onset of labor, from May 2005 to June 2006. <jats:italic>Methods<\/jats:italic>. Two parallel groups were compared: continuation of oxytocin until delivery versus discontinuation of oxytocin at the onset of the active phase. The clinically acceptable increase in mean duration of the active phase of labor (non\u2010inferiority margin) was set at 60 minutes. <jats:italic>Main outcome measures<\/jats:italic>. Primary outcome measure was duration of the active labor phase. Secondary outcome measures included total duration of labor, parameters concerning oxytocin use, rates of uterine hyperstimulation and fetal heart rate (FHR) abnormalities, and mode of delivery. Some neonatal outcomes were also analyzed. <jats:italic>Results<\/jats:italic>. Equivalence of the two strategies (continuation vs. discontinuation of oxytocin) was not demonstrated (<jats:italic>p<\/jats:italic> = 0.97 testing for non\u2010inferiority), the active phase even being significantly longer by a mean of 113 minutes (<jats:italic>p<\/jats:italic> = 0.0001 testing for superiority). The rates of cesarean sections, alterations of FHR and delivery hemorrhage were higher when oxytocin was continued, but not significantly. There were significantly more infants hospitalized in neonatology when oxytocin was continued (<jats:italic>p<\/jats:italic> = 0.028). <jats:italic>Conclusions<\/jats:italic>. Discontinuation of oxytocin at the onset of the active phase prolongs labor. We found no argument for discontinuing the infusion of oxytocin at the onset of the active phase.<\/jats:p>","DOI":"10.1080\/00016340802649816","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T16:15:24Z","timestamp":1232727324000},"page":"172-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Discontinuation of oxytocin in the active phase of labor"],"prefix":"10.1111","volume":"88","author":[{"given":"B\u00c9N\u00c9DICTE","family":"GIRARD","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DELPHINE","family":"VARDON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTIAN","family":"CREVEUIL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHEL","family":"HERLICOVIEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHEL","family":"DREYFUS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00709"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0368-2315(06)76409-2"},{"issue":"4","key":"e_1_2_6_4_2","first-page":"319","article-title":"Enqu\u00eate de pratique nationale aupr\u00e8s des obst\u00e9triciens sur le d\u00e9clenchement artificiel du travail","volume":"28","author":"Goffinet F","year":"1999","journal-title":"J Gynecol Obstet Biol Reprod"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00096.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1540007"},{"issue":"3","key":"e_1_2_6_7_2","first-page":"452","article-title":"The association of maternal weight with cesarean risk, labor duration, and cervical dilation rate during labor induction","volume":"103","author":"Nuthalapaty FS","year":"2004","journal-title":"Obstet Gynecol"},{"issue":"3","key":"e_1_2_6_8_2","first-page":"455","article-title":"Randomized, double\u2010masked comparison of oxytocin dosage in induction and augmentation of labour","volume":"94","author":"Merril DC","year":"1999","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000152338.76759.38"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000157437.10998.e7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2005.00620.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2007.00659.x"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F00016340802649816","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/00016340802649816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T07:38:26Z","timestamp":1697009906000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1080\/00016340802649816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1080\/00016340802649816"],"URL":"https:\/\/doi.org\/10.1080\/00016340802649816","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"2010-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}