{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:23:37Z","timestamp":1768285417726,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":609,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. To evaluate the effect of metformin addition during ovarian hyperstimulation on cycle parameters and outcome of in vitro fertilization (IVF) treatment in polycystic ovary syndrome (PCOS) patients with a body mass index (BMI) &lt;28 kg\/m<jats:sup>2<\/jats:sup>. <jats:italic>Design<\/jats:italic>. Retrospective review of patients\u2019 records. <jats:italic>Setting<\/jats:italic>. Istanbul Memorial Hospital Assisted Reproductive Treatment Unit. <jats:italic>Population<\/jats:italic>. A total of 339 non\u2010obese PCOS patients undergoing IVF were evaluated according to the supplementation of metformin. <jats:italic>Methods<\/jats:italic>. Cycle parameters and IVF outcomes of 220 patients given metformin were compared to those of 119 patients treated without metformin. <jats:italic>Main outcome measures<\/jats:italic>. Implantation and pregnancy rates. <jats:italic>Results<\/jats:italic>. Metformin co\u2010treatment led to significantly lower peak E2 levels (3,481 pg\/ml vs. 4,192 pg\/ml; <jats:italic>p<\/jats:italic> &lt;0.0001). However, gonadotropin consumption, stimulation duration, numbers of total and mature oocytes retrieved, fertilization rate, and ratio of grade I embryos developed were similar in both groups. In the metformin administered group, significantly higher implantation (25% vs. 18%; <jats:italic>p<\/jats:italic> = 0.003) and pregnancy rates (58% vs. 45%; <jats:italic>p<\/jats:italic> = 0.04) were achieved. Abortion and moderate\u2013severe ovarian hyperstimulation syndrome rates were found to be similar in both groups. <jats:italic>Conclusions<\/jats:italic>. Although metformin use was especially and strongly recommended in obese PCOS cases, its supplementation during IVF in PCOS patients with a BMI &lt;28 kg\/m<jats:sup>2<\/jats:sup> was observed to be beneficial and efficacious.<\/jats:p>","DOI":"10.1080\/00016340902835919","type":"journal-article","created":{"date-parts":[[2009,3,20]],"date-time":"2009-03-20T12:23:21Z","timestamp":1237551801000},"page":"563-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy of metformin supplementation during ovarian stimulation of lean PCOS patients undergoing in vitro 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