{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T07:05:32Z","timestamp":1765177532109},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":609,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>. Endostatin, an important anti\u2010angiogenic factor produced by endothelial cells, is elevated in established pre\u2010eclampsia. We measured maternal serum endostatin concentrations in early pregnancy associated with later pre\u2010eclampsia and intrauterine growth retardation (IUGR). <jats:italic>Design<\/jats:italic>. Retrospective case\u2013control study. <jats:italic>Setting<\/jats:italic>. University Central Hospital. <jats:italic>Sample<\/jats:italic>. Serum samples were collected at 12\u201315 and 16\u201320 gestational weeks from a total of 124 pregnant women of whom 49 developed pre\u2010eclampsia, 16 gave birth to infants with IUGR without pre\u2010eclampsia, and 59 remained normotensive giving birth to healthy, normal\u2010weight infants. <jats:italic>Methods<\/jats:italic>. Enzyme\u2010linked immunosorbent assay. <jats:italic>Main outcome measures<\/jats:italic>. Endostatin concentrations in serum. <jats:italic>Results<\/jats:italic>. At 12\u201315 gestational weeks, there was no difference in median endostatin concentrations between the groups. At 16\u201320 gestational weeks, the median endostatin concentration was higher in the women with subsequent pre\u2010eclampsia (<jats:italic>p<\/jats:italic> = 0.026), especially preceding a later severe form of the disease (<jats:italic>p<\/jats:italic> = 0.041), than in the controls. The results were further confirmed by receiver operating characteristic (ROC) analysis showing an area under the curve (AUC) of 0.64 (95% confidence interval: 0.50\u20130.81) for endostatin to identify subsequent pre\u2010eclampsia, and 0.71 (0.53\u20130.89) in cases of severe pre\u2010eclampsia. Optimal cut\u2010off values were determined and used for calculations of sensitivity and specificity, which were 80 and 52% (cut\u2010off value = 58.0 \u03bcg\/L) in pre\u2010eclampsia, and 80 and 65% (cut\u2010off value = 65.5 \u03bcg\/L) in the severe form of the disease. <jats:italic>Conclusions<\/jats:italic>. The concentrations of endostatin in maternal serum at 16\u201320 weeks\u2019 of gestation are associated with an increased risk of pre\u2010eclampsia but not IUGR.<\/jats:p>","DOI":"10.1080\/00016340902838293","type":"journal-article","created":{"date-parts":[[2009,3,24]],"date-time":"2009-03-24T03:48:44Z","timestamp":1237866524000},"page":"593-598","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Maternal serum endostatin at gestational weeks 16\u201320 is elevated in subsequent pre\u2010eclampsia but not in intrauterine growth retardation"],"prefix":"10.1111","volume":"88","author":[{"given":"KATJA\u2010ANNELI","family":"WATH\u00c9N","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OLAVI","family":"YLIKORKALA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STURE","family":"ANDERSSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HENRIK","family":"ALFTHAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ULF\u2010H\u00c5KAN","family":"STENMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PIIA","family":"VUORELA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03577-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00087-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:19:1:103"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0792"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81848-6"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukaryotGeneExpr.v12.i3.20"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.221205198"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.16.4414"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.03.003"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13182.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(03)00142-4"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5903"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.47.28316"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1076"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000249609.04831.7c"},{"key":"e_1_2_6_17_2","first-page":"1541","article-title":"Uudet suomalaiset siki\u00f6n kasvuk\u00e4yr\u00e4t. 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