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The purpose of the present analysis was to analyze and compare the cost\u2010effectiveness of solifenacin flexible dosing (5\u201310 mg) with tolterodine 4 mg sustained release (SR) or placebo (assumed to be comparable to no treatment) for patients with overactive bladder (OAB) symptoms.<jats:italic>Design<\/jats:italic>. A decision\u2010analytic model was constructed.<jats:italic>Methods<\/jats:italic>. Costs and effects were evaluated for the three treatment options in a one\u2010year timeframe. Costs included were treatment costs, cost of pad use, and patients productivity loss based on data from the Nordic countries.<jats:italic>Sample<\/jats:italic>. Results from two randomized controlled trials were used as input data in the cost\u2010effectiveness analysis.<jats:italic>Main outcome measures<\/jats:italic>. Quality adjusted life years and incremental cost\u2010effectiveness ratio.<jats:italic>Results<\/jats:italic>. Solifenacin flexible dosing was more effective with respect to reducing OAB symptoms compared to both placebo and tolterodine 4 mg. Treatment with both solifenacin and tolterodine was more costly compared to placebo, but treatment with solifenacin was a less costly alternative compared to tolterodine 4 mg SR. Sensitivity analyses revealed that the conclusions were robust.<jats:italic>Conclusion<\/jats:italic>. Solifenacin flexible dosing was a cost\u2010effective treatment alternative compared to tolterodine 4 mg SR.<\/jats:p>","DOI":"10.1080\/00016340902849738","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T11:28:40Z","timestamp":1240313320000},"page":"693-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cost\u2010effectiveness analysis of solifenacin flexible dosing in patients with overactive bladder symptoms in four Nordic countries"],"prefix":"10.1111","volume":"88","author":[{"given":"IAN","family":"MILSOM","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SUSANNE","family":"AXELSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SIGURD","family":"KULSENG\u2010HANSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDERS","family":"MATTIASSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CARL GUSTAF","family":"NILSSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JANNIE","family":"WICKSTR\u00d8M","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/nau.10052","article-title":"The standardization of terminology of lower urinary tract function: report from the Standardization Subcommittee of the International Continence Society","volume":"21","author":"Abrams P","year":"2002","journal-title":"Neurol Urodyn"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02228.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.eururo.2006.09.019","article-title":"Population\u2010based survey of urinary incontinence, overactive bladder and other lower urinary tract symptoms in five countries: Results of the EPIC study","volume":"6","author":"Irwin DE","year":"2006","journal-title":"Euro Urol"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.04.018"},{"key":"e_1_2_8_6_2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1080\/pri.20.2.102.107","article-title":"Help\u2010seeking and associated factors in female urinary incontinence. 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