{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:16:05Z","timestamp":1778721365374,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":517,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objectives.<\/jats:italic> To evaluate the performance of cervical phosphorylated insulin\u2010like growth factor binding protein\u20101 (phIGFBP\u20101) testing and cervical length measurement separately and in combination with physician's clinical judgment in prediction of preterm birth among patients with self\u2010reported uterine contractions and intact membranes. <jats:italic>Design.<\/jats:italic> We enrolled a total of 246 women between 22 and 34 weeks of gestation. <jats:italic>Methods.<\/jats:italic> The initial evaluation included cervical length measurement using transvaginal ultrasonography. Short cervix was defined as &lt;25 mm. A swab sample was obtained from the cervix for phIGFBP\u20101. Admission was used as a clinical marker of an increased risk of preterm delivery \u226434 weeks. The diagnostic performances of the tests and clinician's judgment, as well as likelihood ratios (LRs) were calculated. <jats:italic>Main outcome measures.<\/jats:italic> Delivery \u226434 weeks and within 14 days. <jats:italic>Results.<\/jats:italic> The overall rate of spontaneous preterm delivery \u226434 weeks was 4.1% (10\/246). Short cervix, positive phIGFBP\u20101 test, combination of both, and clinician's judgment were all associated with preterm delivery \u226434 weeks or within 14 days (<jats:italic>p<\/jats:italic>&lt;0.01). The negative predictive values for delivery \u226434 weeks were 97.4, 97.6, 97.1, and 98.7%, respectively, and within 14 days 98.7, 99.0, 98.3, and 99.6%, respectively. The corresponding positive LRs for delivery \u226434 weeks were 6.8, 3.8, 75.0, 14.9, and within 14 days 9.7, 5.5, 107.3, 17.1. The negative LRs were 0.6, 0.6, 0.7, 0.3 and 0.5, 0.3, 0.6, 0.2. <jats:italic>Conclusion.<\/jats:italic> The rapid phIGFBP\u20101\u2010test has a high negative predictive value for preterm delivery, comparable to that of ultrasonographic cervical length measurement.<\/jats:p>","DOI":"10.1080\/00016340903104281","type":"journal-article","created":{"date-parts":[[2009,7,3]],"date-time":"2009-07-03T12:52:18Z","timestamp":1246625538000},"page":"901-908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cervical length measurement and cervical phosphorylated insulin\u2010like growth factor binding protein\u20101 testing in prediction of preterm birth in patients reporting uterine contractions"],"prefix":"10.1111","volume":"88","author":[{"given":"LEENA","family":"RAHKONEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEILA","family":"UNKILA\u2010KALLIO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIKA","family":"NUUTILA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUSANNA","family":"SAINIO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TERHI","family":"SAISTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EEVA\u2010MARJA","family":"RUTANEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JORMA","family":"PAAVONEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11476-0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(03)00017-X"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2002.811103.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91000-3"},{"key":"e_1_2_6_6_2","first-page":"765","article-title":"Maternal 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